{"title":"慢性肾脏疾病患者膳食维生素摄入量与心血管疾病患病率的联合和独立关联：一项横断面分析","authors":"Guoqing Wang, Luojun Huang, Wenwen Yue, Jun Feng","doi":"10.3389/fnut.2025.1579313","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Currently, the joint and independent effects of intake of multiple dietary vitamins (including vitamin A, B1, B2, B6, B12, C, D, E, and K) on the prevalence of cardiovascular disease (CVD) in the chronic kidney disease (CKD) population are unclear, so this study was conducted to investigate mainly this point.</p><p><strong>Methods: </strong>We collected National Health and Nutrition Examination Survey (NHANES) data from 2011 to 2016. We performed weighted multivariate logistic regression models to analyze the association of single dietary vitamins intake with CVD. Additionally, we examined the co-exposure of nine dietary vitamins, defined as their concurrent intake, and evaluated the potential additive or interactive effects of co-exposure of nine dietary vitamins on CVD risk in CKD patients using Bayesian kernel machine regression (BKMR) and weighted quantile sum (WQS) regression.</p><p><strong>Results: </strong>Finally, 2,203 CKD participants (weighted <i>n</i> = 27,120,429) were included, and 622 had CVD, with a CVD prevalence of 28.2%. In the fully adjusted model, by comparing the third tertile with the first tertile, the adjusted OR [T3 vs. T1] for the effect of vitamin B6 on CVD prevalence was 0.67 (95% CI, 0.51-0.89, <i>p</i>-value = 0.01), while that of vitamin E was 0.61 (95% CI, 0.42-0.87, <i>p</i>-value = 0.01). In the WQS model, the intake of nine dietary vitamins was negatively correlated with CVD prevalence (OR: 0.81, 95% CI: 0.70-0.93, <i>p</i>-value = 0.004). In the BKMR model, when the concentration was between the 25th and 75th percentiles, there was an overall negative correlation between the total intake of nine dietary vitamins and CVD prevalence.</p><p><strong>Conclusion: </strong>High intakes of vitamin B6 and vitamin E were associated with low CVD risk in CKD patients, respectively. Additionally, nine dietary vitamins (vitamins A, B1, B2, B6, B12, C, D, E, and K) co-exposure were inversely correlated with the CVD prevalence in the CKD populations.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1579313"},"PeriodicalIF":4.0000,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066483/pdf/","citationCount":"0","resultStr":"{\"title\":\"Joint and independent associations of dietary vitamin intake and prevalence of cardiovascular disease in chronic kidney disease subjects: a cross-sectional analysis.\",\"authors\":\"Guoqing Wang, Luojun Huang, Wenwen Yue, Jun Feng\",\"doi\":\"10.3389/fnut.2025.1579313\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Currently, the joint and independent effects of intake of multiple dietary vitamins (including vitamin A, B1, B2, B6, B12, C, D, E, and K) on the prevalence of cardiovascular disease (CVD) in the chronic kidney disease (CKD) population are unclear, so this study was conducted to investigate mainly this point.</p><p><strong>Methods: </strong>We collected National Health and Nutrition Examination Survey (NHANES) data from 2011 to 2016. We performed weighted multivariate logistic regression models to analyze the association of single dietary vitamins intake with CVD. Additionally, we examined the co-exposure of nine dietary vitamins, defined as their concurrent intake, and evaluated the potential additive or interactive effects of co-exposure of nine dietary vitamins on CVD risk in CKD patients using Bayesian kernel machine regression (BKMR) and weighted quantile sum (WQS) regression.</p><p><strong>Results: </strong>Finally, 2,203 CKD participants (weighted <i>n</i> = 27,120,429) were included, and 622 had CVD, with a CVD prevalence of 28.2%. In the fully adjusted model, by comparing the third tertile with the first tertile, the adjusted OR [T3 vs. T1] for the effect of vitamin B6 on CVD prevalence was 0.67 (95% CI, 0.51-0.89, <i>p</i>-value = 0.01), while that of vitamin E was 0.61 (95% CI, 0.42-0.87, <i>p</i>-value = 0.01). In the WQS model, the intake of nine dietary vitamins was negatively correlated with CVD prevalence (OR: 0.81, 95% CI: 0.70-0.93, <i>p</i>-value = 0.004). In the BKMR model, when the concentration was between the 25th and 75th percentiles, there was an overall negative correlation between the total intake of nine dietary vitamins and CVD prevalence.</p><p><strong>Conclusion: </strong>High intakes of vitamin B6 and vitamin E were associated with low CVD risk in CKD patients, respectively. Additionally, nine dietary vitamins (vitamins A, B1, B2, B6, B12, C, D, E, and K) co-exposure were inversely correlated with the CVD prevalence in the CKD populations.</p>\",\"PeriodicalId\":12473,\"journal\":{\"name\":\"Frontiers in Nutrition\",\"volume\":\"12 \",\"pages\":\"1579313\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-04-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066483/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Nutrition\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.3389/fnut.2025.1579313\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Nutrition","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fnut.2025.1579313","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Joint and independent associations of dietary vitamin intake and prevalence of cardiovascular disease in chronic kidney disease subjects: a cross-sectional analysis.
Background: Currently, the joint and independent effects of intake of multiple dietary vitamins (including vitamin A, B1, B2, B6, B12, C, D, E, and K) on the prevalence of cardiovascular disease (CVD) in the chronic kidney disease (CKD) population are unclear, so this study was conducted to investigate mainly this point.
Methods: We collected National Health and Nutrition Examination Survey (NHANES) data from 2011 to 2016. We performed weighted multivariate logistic regression models to analyze the association of single dietary vitamins intake with CVD. Additionally, we examined the co-exposure of nine dietary vitamins, defined as their concurrent intake, and evaluated the potential additive or interactive effects of co-exposure of nine dietary vitamins on CVD risk in CKD patients using Bayesian kernel machine regression (BKMR) and weighted quantile sum (WQS) regression.
Results: Finally, 2,203 CKD participants (weighted n = 27,120,429) were included, and 622 had CVD, with a CVD prevalence of 28.2%. In the fully adjusted model, by comparing the third tertile with the first tertile, the adjusted OR [T3 vs. T1] for the effect of vitamin B6 on CVD prevalence was 0.67 (95% CI, 0.51-0.89, p-value = 0.01), while that of vitamin E was 0.61 (95% CI, 0.42-0.87, p-value = 0.01). In the WQS model, the intake of nine dietary vitamins was negatively correlated with CVD prevalence (OR: 0.81, 95% CI: 0.70-0.93, p-value = 0.004). In the BKMR model, when the concentration was between the 25th and 75th percentiles, there was an overall negative correlation between the total intake of nine dietary vitamins and CVD prevalence.
Conclusion: High intakes of vitamin B6 and vitamin E were associated with low CVD risk in CKD patients, respectively. Additionally, nine dietary vitamins (vitamins A, B1, B2, B6, B12, C, D, E, and K) co-exposure were inversely correlated with the CVD prevalence in the CKD populations.
期刊介绍：
No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health.
Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.
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