{"title":"美国成年女性中性粒细胞百分比与白蛋白比率与乳腺癌之间的关系：来自NHANES的研究结果。","authors":"Huikai Liang, Kelun Pan, Jiayi Wang, Jianqing Lin","doi":"10.3389/fnut.2025.1533636","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>An increasing number of studies suggests an association between systemic inflammation, nutritional status, and cancer. However, the relationship between the prevalence of breast cancer (BC) and the neutrophil-percentage-to-albumin ratio (NPAR), a recently identified biomarker of inflammation, is not well established. Therefore, this study aims to investigate the relationship between BC risk and the NPAR.</p><p><strong>Methods: </strong>This study included 18,726 participants from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2018. The NPAR was used to assess inflammation and nutritional status. Statistical methods such as multivariate logistic regression, subgroup analysis, and restricted cubic spline (RCS) analysis were conducted to investigate the influence of NPAR on the prevalence of BC. In addition, propensity score matching was employed to further validate the findings.</p><p><strong>Results: </strong>The logistic regression results showed that the prevalence of breast cancer is significantly associated with the NPAR (OR = 1.05; 95% CI = 1.02-1.09, <i>p</i> = 0.003). In comparison to participants in the lowest quartile, Q1, the prevalence of breast cancer increased by 5% for those in Q2 (<i>p</i> = 0.745), 3% for those in Q3 (<i>p</i> = 0.032), and 38% for those in Q4 (<i>p</i> = 0.018) with a higher NPAR. In addition, subgroup and RCS analyses showed that the NPAR and BC prevalence were positively correlated. Furthermore, a significant association was observed between the NPAR and marital status. The significance of traits was assessed using mean decrease accuracy (MDA) and mean decrease impurity (MDI). These measures of random forest modeling showed that NPAR is one of the major factors affecting the prevalence of BC. Furthermore, linear analysis demonstrated a correlation between a high NPAR and increased total testosterone and sex hormone-binding globulin (SHBG) levels.</p><p><strong>Conclusion: </strong>A significant association was observed between a high NPAR and a higher prevalence of breast cancer, which could be attributable to sex hormone levels. This finding suggests that the NPAR may serve as a biomarker for BC in adult women in the US.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1533636"},"PeriodicalIF":4.0000,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066505/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between neutrophil percentage-to-albumin ratio and breast cancer in adult women in the US: findings from the NHANES.\",\"authors\":\"Huikai Liang, Kelun Pan, Jiayi Wang, Jianqing Lin\",\"doi\":\"10.3389/fnut.2025.1533636\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>An increasing number of studies suggests an association between systemic inflammation, nutritional status, and cancer. However, the relationship between the prevalence of breast cancer (BC) and the neutrophil-percentage-to-albumin ratio (NPAR), a recently identified biomarker of inflammation, is not well established. Therefore, this study aims to investigate the relationship between BC risk and the NPAR.</p><p><strong>Methods: </strong>This study included 18,726 participants from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2018. The NPAR was used to assess inflammation and nutritional status. Statistical methods such as multivariate logistic regression, subgroup analysis, and restricted cubic spline (RCS) analysis were conducted to investigate the influence of NPAR on the prevalence of BC. In addition, propensity score matching was employed to further validate the findings.</p><p><strong>Results: </strong>The logistic regression results showed that the prevalence of breast cancer is significantly associated with the NPAR (OR = 1.05; 95% CI = 1.02-1.09, <i>p</i> = 0.003). In comparison to participants in the lowest quartile, Q1, the prevalence of breast cancer increased by 5% for those in Q2 (<i>p</i> = 0.745), 3% for those in Q3 (<i>p</i> = 0.032), and 38% for those in Q4 (<i>p</i> = 0.018) with a higher NPAR. In addition, subgroup and RCS analyses showed that the NPAR and BC prevalence were positively correlated. Furthermore, a significant association was observed between the NPAR and marital status. The significance of traits was assessed using mean decrease accuracy (MDA) and mean decrease impurity (MDI). These measures of random forest modeling showed that NPAR is one of the major factors affecting the prevalence of BC. Furthermore, linear analysis demonstrated a correlation between a high NPAR and increased total testosterone and sex hormone-binding globulin (SHBG) levels.</p><p><strong>Conclusion: </strong>A significant association was observed between a high NPAR and a higher prevalence of breast cancer, which could be attributable to sex hormone levels. This finding suggests that the NPAR may serve as a biomarker for BC in adult women in the US.</p>\",\"PeriodicalId\":12473,\"journal\":{\"name\":\"Frontiers in Nutrition\",\"volume\":\"12 \",\"pages\":\"1533636\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-04-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066505/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Nutrition\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.3389/fnut.2025.1533636\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Nutrition","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fnut.2025.1533636","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Association between neutrophil percentage-to-albumin ratio and breast cancer in adult women in the US: findings from the NHANES.
Background: An increasing number of studies suggests an association between systemic inflammation, nutritional status, and cancer. However, the relationship between the prevalence of breast cancer (BC) and the neutrophil-percentage-to-albumin ratio (NPAR), a recently identified biomarker of inflammation, is not well established. Therefore, this study aims to investigate the relationship between BC risk and the NPAR.
Methods: This study included 18,726 participants from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2018. The NPAR was used to assess inflammation and nutritional status. Statistical methods such as multivariate logistic regression, subgroup analysis, and restricted cubic spline (RCS) analysis were conducted to investigate the influence of NPAR on the prevalence of BC. In addition, propensity score matching was employed to further validate the findings.
Results: The logistic regression results showed that the prevalence of breast cancer is significantly associated with the NPAR (OR = 1.05; 95% CI = 1.02-1.09, p = 0.003). In comparison to participants in the lowest quartile, Q1, the prevalence of breast cancer increased by 5% for those in Q2 (p = 0.745), 3% for those in Q3 (p = 0.032), and 38% for those in Q4 (p = 0.018) with a higher NPAR. In addition, subgroup and RCS analyses showed that the NPAR and BC prevalence were positively correlated. Furthermore, a significant association was observed between the NPAR and marital status. The significance of traits was assessed using mean decrease accuracy (MDA) and mean decrease impurity (MDI). These measures of random forest modeling showed that NPAR is one of the major factors affecting the prevalence of BC. Furthermore, linear analysis demonstrated a correlation between a high NPAR and increased total testosterone and sex hormone-binding globulin (SHBG) levels.
Conclusion: A significant association was observed between a high NPAR and a higher prevalence of breast cancer, which could be attributable to sex hormone levels. This finding suggests that the NPAR may serve as a biomarker for BC in adult women in the US.
期刊介绍：
No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health.
Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
