肿瘤微环境和自组织在癌症进展中的作用:治疗发展的关键见解。

IF 2.2 4区 工程技术 Q3 PHARMACOLOGY & PHARMACY
Bioimpacts Pub Date : 2024-12-07 eCollection Date: 2025-01-01 DOI:10.34172/bi.30713
Milad Asadi, Venus Zafari, Sanam Sadeghi-Mohammadi, Dariush Shanehbandi, Ufuk Mert, Zahra Soleimani, Ayşe Caner, Habib Zarredar
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引用次数: 0

摘要

肿瘤微环境(tumor microenvironment, TME)在肿瘤进展中起关键作用,影响肿瘤的发生、生长、侵袭、转移和对治疗的反应。本研究探讨了TME内的动态相互作用,特别关注自组织-肿瘤细胞及其微环境相互塑造的过程,导致癌症进展和耐药性。了解这些相互作用可以揭示TME内新的预后标志物和治疗靶点,如细胞外基质(ECM)成分、免疫细胞和细胞因子信号通路。方法:采用综合检索方法调查当前关于TME的学术文献,特别关注PubMed、谷歌Scholar和Science Direct数据库中癌症进展和耐药背景下的自组织。结果:最近的研究表明,破坏TME自组织的治疗可以通过击败耐药性和提高常规治疗的有效性来改善患者的预后。此外,本研究强调了了解TME的生物物理特性(如细胞骨架改变)在开发更有效的恶性肿瘤治疗中的重要性。结论:本文综述表明,靶向TME内的ECM和免疫细胞可提高治疗效果。此外,通过关注TME自组织,我们可以发现新的治疗方案来战胜耐药性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of tumor microenvironment and self-organization in cancer progression: Key insights for therapeutic development.

Introduction: The tumor microenvironment (TME) plays a pivotal role in cancer progression, influencing tumor initiation, growth, invasion, metastasis, and response to therapies. This study explores the dynamic interactions within the TME, particularly focusing on self-organization-a process by which tumor cells and their microenvironment reciprocally shape one another, leading to cancer progression and resistance. Understanding these interactions can reveal new prognostic markers and therapeutic targets within the TME, such as extracellular matrix (ECM) components, immune cells, and cytokine signaling pathways.

Methods: A comprehensive search method was employed to investigate the current academic literature on TME, particularly focusing on self-organization in the context of cancer progression and resistance across the PubMed, Google Scholar, and Science Direct databases.

Results: Recent studies suggest that therapies that disrupt TME self-organization could improve patient outcomes by defeating drug resistance and increasing the effectiveness of conventional therapy. Additionally, this research highlights the essential of understanding the biophysical properties of the TME, like cytoskeletal alterations, in the development of more effective malignancy therapy.

Conclusion: This review indicated that targeting the ECM and immune cells within the TME can improve therapy effectiveness. Also, by focusing on TME self-organization, we can recognize new therapeutic plans to defeat drug resistance.

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来源期刊
Bioimpacts
Bioimpacts Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
4.80
自引率
7.70%
发文量
36
审稿时长
5 weeks
期刊介绍: BioImpacts (BI) is a peer-reviewed multidisciplinary international journal, covering original research articles, reviews, commentaries, hypotheses, methodologies, and visions/reflections dealing with all aspects of biological and biomedical researches at molecular, cellular, functional and translational dimensions.
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