阿尔茨海默病胶质淋巴系统诊断影像学研究进展。

IF 3.5 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2025-05-08 DOI:10.1016/j.brainresbull.2025.111377

Feiyue Mi, Xiaoyan Yang, Xueyan Huang, Gaoqiang Xu, Dongfeng Pan, Changyin Yu

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引用次数: 0

摘要

胶质淋巴系统（GLS）通过与间质液（ISF）交换物质，负责清除脑内代谢废物和异常沉积物质，从而维持脑内稳态。该系统功能障碍可导致淀粉样蛋白（Aβ）和tau蛋白的异常积累，从而导致认知障碍。神经影像学的最新进展增强了GLS功能的评估，形成了阿尔茨海默病（AD）诊断的重要组成部分。本文全面概述了用于阿尔茨海默病（AD）神经胶质淋巴系统可视化的各种方法的成像性能，并强调了各自的优点和局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advances in Diagnostic Imaging of the Glial Lymphatic System in Alzheimer's Disease.

The glial lymphatic system (GLS) is responsible for removing metabolic waste and aberrantly deposited substances from brain by exchanging materials with interstitial fluid (ISF), thereby maintaining cerebral homeostasis. Dysfunction in this system can result in the abnormal accumulation of amyloid-beta (Aβ) and tau proteins, leading to cognitive impairments. Recent advancements in neuroimaging have enhanced the evaluation of GLS function, forming a vital component of Alzheimer's disease (AD) diagnostics. This article offers a comprehensive overview of the imaging performance of various methods used to visualize the glial lymphatic system in Alzheimer's disease (AD), highlighting their respective advantages and limitations.

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.