{"title":"探讨热熔挤压从工艺到产品的方法和药物输送应用：综述。","authors":"Praveen Halagali, Mahalaxmi Rathnanand, Vamshi Krishna Tippavajhala","doi":"10.2174/0113816128357733250324054151","DOIUrl":null,"url":null,"abstract":"<p><p>For the pharmaceutical industry, hot-melt extrusion (HME) has become a cutting-edge production process. Compared to conventional procedures, HME is a solvent-free approach that offers numerous applications, cost-effectiveness, and continuous manufacturing. Studying the formulation and process characteristics should be prioritized in order to satisfy requirements. Many distinct dosage forms for different purposes can be formulated by altering the equipment design and a few processing parameters. For the intended outcome, the HME process must run smoothly and continuously. In this regard, pre-formulation study plays a main role in selecting the carrier, drug, and other required excipients. This review provides a comprehensive understanding of various equipment parts, HME materials and processes, formulation development, and HME in the delivery of drugs. It also highlights the applications and patents of HME.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring Hot Melt Extrusion from Process to Product with Methodologies and Drug-Delivery Applications: A Review.\",\"authors\":\"Praveen Halagali, Mahalaxmi Rathnanand, Vamshi Krishna Tippavajhala\",\"doi\":\"10.2174/0113816128357733250324054151\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>For the pharmaceutical industry, hot-melt extrusion (HME) has become a cutting-edge production process. Compared to conventional procedures, HME is a solvent-free approach that offers numerous applications, cost-effectiveness, and continuous manufacturing. Studying the formulation and process characteristics should be prioritized in order to satisfy requirements. Many distinct dosage forms for different purposes can be formulated by altering the equipment design and a few processing parameters. For the intended outcome, the HME process must run smoothly and continuously. In this regard, pre-formulation study plays a main role in selecting the carrier, drug, and other required excipients. This review provides a comprehensive understanding of various equipment parts, HME materials and processes, formulation development, and HME in the delivery of drugs. It also highlights the applications and patents of HME.</p>\",\"PeriodicalId\":10845,\"journal\":{\"name\":\"Current pharmaceutical design\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-04-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current pharmaceutical design\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/0113816128357733250324054151\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current pharmaceutical design","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0113816128357733250324054151","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Exploring Hot Melt Extrusion from Process to Product with Methodologies and Drug-Delivery Applications: A Review.
For the pharmaceutical industry, hot-melt extrusion (HME) has become a cutting-edge production process. Compared to conventional procedures, HME is a solvent-free approach that offers numerous applications, cost-effectiveness, and continuous manufacturing. Studying the formulation and process characteristics should be prioritized in order to satisfy requirements. Many distinct dosage forms for different purposes can be formulated by altering the equipment design and a few processing parameters. For the intended outcome, the HME process must run smoothly and continuously. In this regard, pre-formulation study plays a main role in selecting the carrier, drug, and other required excipients. This review provides a comprehensive understanding of various equipment parts, HME materials and processes, formulation development, and HME in the delivery of drugs. It also highlights the applications and patents of HME.
期刊介绍：
Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field.
Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.
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