{"title":"抗癫痫药物引起的儿童癫痫认知障碍:一个叙述性的回顾。","authors":"Negin Armide, Meisam Babaei","doi":"10.22037/ijcn.v19i2.46371","DOIUrl":null,"url":null,"abstract":"<p><p>Several circumstances, including the etiology of epilepsy, its early onset, recurrent seizures, and the use of anti-seizure medications (ASMs), can lead to cognitive impairment in people with epilepsy. Studies indicate that the etiology of epilepsy may be more closely associated with cognitive problems than the ASMs. However, considering long-term treatment in pediatrics and their developing nervous systems, it is critical to understand the cognitive effects of each anti-seizure medication. Significant methodological challenges exist in studying the cognitive effects of ASMs. Accordingly, this review aims to give a broad overview of recent studies on cognitive impairment caused by first- and second-generation ASMs.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 2","pages":"9-25"},"PeriodicalIF":0.8000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994136/pdf/","citationCount":"0","resultStr":"{\"title\":\"Anti-seizure Medication Induced Cognitive Impairment in Children with Epilepsy: A Narrative Review.\",\"authors\":\"Negin Armide, Meisam Babaei\",\"doi\":\"10.22037/ijcn.v19i2.46371\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Several circumstances, including the etiology of epilepsy, its early onset, recurrent seizures, and the use of anti-seizure medications (ASMs), can lead to cognitive impairment in people with epilepsy. Studies indicate that the etiology of epilepsy may be more closely associated with cognitive problems than the ASMs. However, considering long-term treatment in pediatrics and their developing nervous systems, it is critical to understand the cognitive effects of each anti-seizure medication. Significant methodological challenges exist in studying the cognitive effects of ASMs. Accordingly, this review aims to give a broad overview of recent studies on cognitive impairment caused by first- and second-generation ASMs.</p>\",\"PeriodicalId\":14537,\"journal\":{\"name\":\"Iranian Journal of Child Neurology\",\"volume\":\"19 2\",\"pages\":\"9-25\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994136/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Child Neurology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22037/ijcn.v19i2.46371\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/11 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Child Neurology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22037/ijcn.v19i2.46371","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/11 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Anti-seizure Medication Induced Cognitive Impairment in Children with Epilepsy: A Narrative Review.
Several circumstances, including the etiology of epilepsy, its early onset, recurrent seizures, and the use of anti-seizure medications (ASMs), can lead to cognitive impairment in people with epilepsy. Studies indicate that the etiology of epilepsy may be more closely associated with cognitive problems than the ASMs. However, considering long-term treatment in pediatrics and their developing nervous systems, it is critical to understand the cognitive effects of each anti-seizure medication. Significant methodological challenges exist in studying the cognitive effects of ASMs. Accordingly, this review aims to give a broad overview of recent studies on cognitive impairment caused by first- and second-generation ASMs.