Jia-Li He, Yu Wang, Xiang-Xi Yi, Yu-Man Gan, Yong-Hong Liu, Cheng-Hai Gao, Kai Liu, Meng Bai
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Bioactive Sesterterpenoids from the Mangrove-Derived Aspergillus sp. GXIMD 03023.
Four novel sesterterpenoids, asperterpenoids Q-T (1-4), featuring a rare 5/7/(3)6/5 pentacyclic skeleton were isolated from the mangrove-derived fungus Aspergillus sp. GXIMD 03023 using an NMR-guided approach. Their structures and absolute configurations were determined by comprehensive spectroscopic analysis, including 1D/2D-NMR and HRESIMS, supplemented by experimental and ECD spectral matching, DFT-calculated 13C NMR chemical shifts, and DP4plus probability analysis. Compounds 1-4 were screened for antibacterial activity and benign prostatic hyperplasia (BPH) inhibitory activity. Compound 1 showed weak activity against Vibrio harveyi and Xanthomonas campestris, with MIC values of 3.12 and 6.25 μg/mL, respectively. Compound 3 had significant inhibitory activity against BPH with an IC50 value of 3.68 μM.
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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