Yi Hua, Gangao Hu, Titi Ying, Jiangwei Pan, Zhenyi Zhou, Cuixian Zhang, Hong Wang, Bin Wei
{"title":"致病真菌Corynespora属：生物活性次生代谢物的多产来源。","authors":"Yi Hua, Gangao Hu, Titi Ying, Jiangwei Pan, Zhenyi Zhou, Cuixian Zhang, Hong Wang, Bin Wei","doi":"10.1021/acs.jnatprod.5c00145","DOIUrl":null,"url":null,"abstract":"<p><p>In this perspective, we examine the chemical structures and biological activities of 55 secondary metabolites isolated from the pathogenic fungal genus <i>Corynespora</i>. Over 20% of these compounds demonstrate bioactivities, including antibacterial, anticancer, enzyme inhibition, and others. Bioinformatic analysis reveals that <i>Corynespora</i> possesses a high potential for encoding PKS-I and NRPS natural products, including many clade-specific metabolites, and only 2.1% of biosynthetic gene cluster families are associated with known secondary metabolites. This study underscores the significant, unexplored potential of <i>Corynespora</i> strains for synthesizing novel secondary metabolites, providing valuable insights into the targeted discovery and biosynthesis of novel natural products from this genus.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":"1259-1269"},"PeriodicalIF":3.3000,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Pathogenic Fungal Genus Corynespora: A Prolific Source of Bioactive Secondary Metabolites.\",\"authors\":\"Yi Hua, Gangao Hu, Titi Ying, Jiangwei Pan, Zhenyi Zhou, Cuixian Zhang, Hong Wang, Bin Wei\",\"doi\":\"10.1021/acs.jnatprod.5c00145\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In this perspective, we examine the chemical structures and biological activities of 55 secondary metabolites isolated from the pathogenic fungal genus <i>Corynespora</i>. Over 20% of these compounds demonstrate bioactivities, including antibacterial, anticancer, enzyme inhibition, and others. Bioinformatic analysis reveals that <i>Corynespora</i> possesses a high potential for encoding PKS-I and NRPS natural products, including many clade-specific metabolites, and only 2.1% of biosynthetic gene cluster families are associated with known secondary metabolites. This study underscores the significant, unexplored potential of <i>Corynespora</i> strains for synthesizing novel secondary metabolites, providing valuable insights into the targeted discovery and biosynthesis of novel natural products from this genus.</p>\",\"PeriodicalId\":47,\"journal\":{\"name\":\"Journal of Natural Products \",\"volume\":\" \",\"pages\":\"1259-1269\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-05-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Natural Products \",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1021/acs.jnatprod.5c00145\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/24 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Products ","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1021/acs.jnatprod.5c00145","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/24 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
The Pathogenic Fungal Genus Corynespora: A Prolific Source of Bioactive Secondary Metabolites.
In this perspective, we examine the chemical structures and biological activities of 55 secondary metabolites isolated from the pathogenic fungal genus Corynespora. Over 20% of these compounds demonstrate bioactivities, including antibacterial, anticancer, enzyme inhibition, and others. Bioinformatic analysis reveals that Corynespora possesses a high potential for encoding PKS-I and NRPS natural products, including many clade-specific metabolites, and only 2.1% of biosynthetic gene cluster families are associated with known secondary metabolites. This study underscores the significant, unexplored potential of Corynespora strains for synthesizing novel secondary metabolites, providing valuable insights into the targeted discovery and biosynthesis of novel natural products from this genus.
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
