槲皮素通过tas2r38介导的PLC信号通路促进肠内分泌l细胞GLP-1分泌

IF 4.5 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Molecular Nutrition & Food Research Pub Date : 2025-05-13 DOI:10.1002/mnfr.70109

Chenxuan Wang,Jiefang Zhou,Xiaojing Liu,Fengmei Zhu,Jun Li,Wentao Xu,Jinjin Liu

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引用次数: 0

摘要

槲皮素（QC）是一种天然的类黄酮，通过促进胰高血糖素样肽-1 （GLP-1）的分泌来调节葡萄糖稳态。本研究探讨苦味受体TAS2R38和磷脂酶C （PLC）信号通路在qc诱导的肠内分泌NCI-H716细胞GLP-1分泌中的作用。分子对接显示QC与TAS2R38之间存在较强的结合。QC能显著增强GLP-1的分泌，而TAS2R38 siRNA和PLC抑制剂能减弱GLP-1的分泌。这些发现表明QC通过tas2r38介导的PLC信号通路刺激GLP-1的释放，为QC的降糖作用提供了一种新的机制。

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Quercetin Enhances GLP-1 Secretion via TAS2R38-Mediated PLC Signaling in Enteroendocrine L-Cells.

Quercetin (QC), a natural flavonoid, has shown potential in regulating glucose homeostasis by promoting glucagon-like peptide-1 (GLP-1) secretion. This study investigates the role of the bitter taste receptor TAS2R38 and the phospholipase C (PLC) signaling pathway in QC-induced GLP-1 secretion from enteroendocrine NCI-H716 cells. Molecular docking revealed strong binding between QC and TAS2R38. QC significantly enhanced GLP-1 secretion, which was attenuated by TAS2R38 siRNA and PLC inhibitors. These findings suggest that QC stimulates GLP-1 release through TAS2R38-mediated PLC signaling, offering a novel mechanism for QC's antidiabetic effects.

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来源期刊

Molecular Nutrition & Food Research 工程技术-食品科技

CiteScore

8.70

自引率

1.90%

发文量

250

审稿时长

1.7 months

期刊介绍： Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.