枸杞枸杞亚精胺L通过靶向uc.141A促进抗生素诱导大鼠肠道修复

IF 6.2 1区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of Agricultural and Food Chemistry Pub Date : 2025-05-12 DOI:10.1021/acs.jafc.5c00328

Xueni Zhang,Xiaoyan Wen,Di Zhou,Zhengqun Zhou,Gang Chen,Wei Li,Hao Gao,Ning Li

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引用次数: 0

摘要

口服抗生素在治疗感染时损害肠道上皮。枸杞源自枸杞，是一种具有促进肠道健康作用的膳食和滋补草药。其中的亚精胺化合物枸杞亚精胺L （LBS L）能促进肠道上皮的生长。本研究的目的是研究LBS L对抗生素刺激的肠道上皮损伤的修复作用，以及与T-UCR相关的过程。用抗生素刺激肠上皮细胞诱导损伤。通过细胞分析评估LBS - L和t - ucr相关机制的影响。最后，通过给药建立了大鼠肠道损伤模型。我们发现LBS L通过调节uc.141A/miR195-3p逆转抗生素引起的肠道损伤。在大鼠模型中观察到肠道损伤的减少。综上所述，LBS L通过调节uc.141A来改善抗生素诱导的大鼠肠上皮细胞损伤。

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Lycibarbarspermidine L from Goji Berry Promotes Intestinal Restoration in an Antibiotic-Induced Rat Model through Targeting uc.141A.

Oral antibiotics damage gut epithelium while treating infections. Goji berry derives from Lycium barbarum L., which is employed as a dietary and tonic herb with the effect of promoting intestinal health. The spermidine compound lycibarbarspermidine L (LBS L) in it can promote intestinal epithelial growth. The purpose of the research is to examine the reparative effects of LBS L against antibiotic-stimulated gut epithelial damage, as well as the processes associated with T-UCR. Intestinal epithelial cells were stimulated with antibiotics to induce injury. The impact of LBS L and T-UCR-related mechanisms was evaluated through cell assays. Ultimately, a rat model of intestinal injury was developed by administering antibiotics. We found that LBS L reversed the intestinal damage caused by antibiotics through modulating uc.141A/miR195-3p. A reduction in intestinal damage was observed in rat models. In conclusion, LBS L ameliorates antibiotic-induced intestinal epithelial cell damage in rats by modulating uc.141A.

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来源期刊

Journal of Agricultural and Food Chemistry 农林科学-农业综合

CiteScore

9.90

自引率

8.20%

发文量

1375

审稿时长

2.3 months

期刊介绍： The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.