血液生物标志物与脆弱性的关联-制图综述

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-05-01 DOI:10.1016/j.arr.2025.102761

Lea Fritzenschaft , Felix Boehm , Dietrich Rothenbacher , Michael Denkinger , Dhayana Dallmeier

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引用次数: 0

摘要

虚弱描述了一种老年综合症，其特征是脆弱性增加。尽管已经讨论了各种潜在的基于血液的生物标志物的表征，但考虑到基于血液的生物标志物用于这一目的的可靠方案仍然缺失。然而，全面概述这些生物标志物是必要的，以了解潜在的分子途径脆弱。因此，我们进行了一项图谱回顾，以确定那些与社区居住老年人虚弱最一致的血液生物标志物，以及根据现有文献可能存在的分析空白。考虑到可用出版物的数量以及研究人群的大小，计算每个生物标志物的加权相关指数（CI），该指数描述了关联的方向和一致性。总的来说，72篇论文被严格审查，总共报告了82个生物标志物。在未调整和完全调整的模型中，至少有3篇文章对各自的生物标志物进行了最一致的正相关研究，其中白细胞介素6 （IL-6）、高敏c反应蛋白（hs-CRP）、新蝶呤、白细胞计数、糖化血红蛋白A1c （HbA1c）和性激素结合球蛋白（SHBG）的CI≥ 0.7，而血红蛋白、25-羟基维生素D、男性游离睾酮和白蛋白的CI≤ -0.7为负相关。

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Association of blood biomarkers with frailty–A mapping review

Frailty describes a geriatric syndrome characterized by an increased vulnerability. Although a variety of potential blood-based biomarkers have been discussed for its characterization, a reliable protocol considering blood-based biomarkers for this purpose is still missing. However, a comprehensive overview on these biomarkers is necessary to understand potential molecular pathways to frailty. We, therefore, performed a mapping review to identify those blood-based biomarkers most consistently associated with frailty in community-dwelling older adults as well as possible analytical gaps according to the available literature. A proposed weighted correlation index (CI) describing the direction and consistency of the association considering the number of available publications as well as the size of the study populations was calculated for each biomarker. Overall, 72 manuscripts were critically reviewed reporting on a total of 82 biomarkers. The most consistent positive association with at least 3 articles addressing the respective biomarker in unadjusted and fully adjusted models was shown for interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), neopterin, white blood cells count, glycated hemoglobin A1c (HbA1c) and sex hormone binding-globuline (SHBG) with a CI ≥ 0.7, while for negative association hemoglobin, 25-hydroxy vitamin D, free testosterone in men and albumin with a CI ≤ -0.7 were identified.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.