研究报告：揭示卵黄转铁蛋白对鸡原始生殖细胞生物学过程的影响

IF 3.8 1区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Poultry Science Pub Date : 2025-05-03 DOI:10.1016/j.psj.2025.105259

Xin Liu , Yixiu Peng , Jun Wu , Hongwu Qian , Xiaoqian Lv , Fan Li , Kai Jin , Yingjie Niu , Jiuzhou Song , Wei Han , Guohong Chen , Bichun Li , Qisheng Zuo

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引用次数: 0

摘要

在遗传育种领域，原始生殖细胞（PGCs）因其独特的发育潜力和遗传特性，已成为基因编辑和遗传改良的必备细胞。然而，培养系统的增殖效率低和不稳定性给PGCs在遗传育种中的应用带来了重大挑战。在本研究中，卵黄转铁蛋白对鸡PGCs的生物学效应，重点关注其在调节关键细胞过程中的作用。0.5 mg/ml卵转铁蛋白可显著促进培养的PGCs细胞增殖，增强细胞粘附，降低氧化应激，抑制凋亡。这些发现揭示了卵转铁蛋白在维持PGC存活和功能中的调节作用，为通过靶向调节细胞命运来优化PGC培养系统提供了新的见解。

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Research note: Unveiling the impact of ovotransferrin on chicken primordial germ cells biological processes

In the field of genetic breeding, primordial germ cells (PGCs) have become essential cells for gene editing and genetic improvement due to their unique developmental potential and genetic characteristics. However, the low proliferation efficiency and instability of culture systems pose significant challenges, severely limiting the application of PGCs in genetic breeding. In this study, the biological effects of ovotransferrin on chicken PGCs, focusing on its role in regulating key cellular processes. Treatment with 0.5 mg/ml ovotransferrin significantly promoted cell proliferation, enhanced cell adhesion, reduced oxidative stress, and suppressed apoptosis in cultured PGCs. These findings reveal a regulatory role of ovotransferrin in maintaining PGCs survival and function, providing new insights into optimizing PGC culture systems through targeted modulation of cell fate.

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来源期刊

Poultry Science 农林科学-奶制品与动物科学

CiteScore

7.60

自引率

15.90%

发文量

审稿时长

94 days

期刊介绍： First self-published in 1921, Poultry Science is an internationally renowned monthly journal, known as the authoritative source for a broad range of poultry information and high-caliber research. The journal plays a pivotal role in the dissemination of preeminent poultry-related knowledge across all disciplines. As of January 2020, Poultry Science will become an Open Access journal with no subscription charges, meaning authors who publish here can make their research immediately, permanently, and freely accessible worldwide while retaining copyright to their work. Papers submitted for publication after October 1, 2019 will be published as Open Access papers. An international journal, Poultry Science publishes original papers, research notes, symposium papers, and reviews of basic science as applied to poultry. This authoritative source of poultry information is consistently ranked by ISI Impact Factor as one of the top 10 agriculture, dairy and animal science journals to deliver high-caliber research. Currently it is the highest-ranked (by Impact Factor and Eigenfactor) journal dedicated to publishing poultry research. Subject areas include breeding, genetics, education, production, management, environment, health, behavior, welfare, immunology, molecular biology, metabolism, nutrition, physiology, reproduction, processing, and products.