斑马鱼作为嗅觉研究的模型：从分子机制到技术应用的系统综述

IF 9.8 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Chemistry Pub Date : 2025-05-11 DOI:10.1016/j.foodchem.2025.144698

JianCai Zhu , YingQian Chen , XiaoJie Liu , ZhenChun Sun , Jing Zhang , TianYin Shen , YunWei Niu , ZuoBing Xiao

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引用次数: 0

摘要

斑马鱼具有独特的生物学特性，可以作为研究嗅觉机制的理想模型。本文综述了它们的嗅觉系统，重点介绍了受体基因表达的调控、气味识别的机制以及行为分析、分子对接和生物技术方法等研究方法。目前的限制主要包括定性数据，跨物种比较不足，以及环境调节机制不清楚。尽管如此，斑马鱼模型在破译人类嗅觉和在神经科学、生物技术、医疗保健、食品安全和环境监测方面的应用方面显示出巨大的潜力。未来的研究应建立跨物种嗅觉数据库，规范行为评估，解决技术瓶颈，以推进在精准医疗、食品质量控制和污染物检测方面的应用。

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Zebrafish as a model for olfactory research: A systematic review from molecular mechanism to technology application

Zebrafish with unique biological traits can serve as an ideal model for studying olfactory mechanisms. This review analyzes their olfactory system, focusing on the regulation of receptor gene expression, mechanisms of odor recognition, and research methodologies including behavioral assays, molecular docking, and biotechnological approaches. Current limitations include predominantly qualitative data, insufficient cross-species comparisons, and unclear mechanisms of environmental modulation. Nevertheless, zebrafish models show significant potential in deciphering human olfaction and applications in neuroscience, biotechnology, healthcare, food safety, and environmental monitoring. Future research should establish cross-species olfactory databases, standardize behavioral assessments, and resolve technical bottlenecks to advance applications in precision medicine, food quality control, and pollutant detection.

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来源期刊

Food Chemistry 工程技术-食品科技

CiteScore

16.30

自引率

10.20%

发文量

3130

审稿时长

122 days

期刊介绍： Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.