家鸡黑色素对环磷酰胺诱导的免疫抑制的免疫调节作用

IF 3.8 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY
Jiao Liu, Haiyun Gao, Tianrui Liu, Tian Zhang, Tiegui Nan, Hongmei Li, Hiu Li, Jianliang Li, Yuan Yuan
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引用次数: 0

摘要

乌骨鸡(Gallus Gallus domesticus Brisson),药用食品同源,用于提高人体免疫力。然而,其生物活性成分之一黑骨丝鸡黑色素(BSFM)是否会影响免疫功能尚不清楚。本研究旨在探讨BSFM在环磷酰胺诱导的免疫抑制小鼠模型中的免疫调节作用及其机制。结果表明:BSFM能显著提高外周血白细胞(WBC);上调血浆中IL-4、TNF-α、M-CSF的表达;减少组织损伤。在机制上,蛋白质组学研究显示BSFM治疗显著影响了29种蛋白(Mtatp6、Cst3、Pglyrp1、Igkc等靶点)的数量,这些蛋白主要参与磷脂酰胆碱分解代谢过程、IIa型超敏反应的正调节、脂质分解代谢过程和中性粒细胞趋化性。代谢组学表明,BSFM降低了辛烷酰葡萄糖醛酸、Gly-Gly和n - α -乙酰鸟氨酸的水平,并调节了精氨酸的生物合成。此外,BSFM处理改变了肠道微生物群的组成,增加了Prevotella、S24-7、Olsenella、Lactococcus、hcl -clade、Parasutterella和Acetobacter的相对丰度。通过Pearson相关分析,炎症相关参数、肠道微生物群和各种代谢物(DMs)之间存在显著相关性,改变了肠道微生物群的组成。这些发现表明,BSFM有望增强人体免疫系统,并可能作为传统化疗的补充疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Immune Regulation of Melanin From Gallus gallus domesticus Brisson Against Cyclophosphamide-Induced Immunosuppression

The Immune Regulation of Melanin From Gallus gallus domesticus Brisson Against Cyclophosphamide-Induced Immunosuppression

Black-bone silky fowl (Gallus gallus domesticus Brisson), medicinal food homology, utilizes to enhance human immunity. However, it remains unclear whether Black-bone silky fowl melanin (BSFM), one of its bioactive components, could affect immune function. The purpose of this study is to examine the immunoregulatory effect and the underlying mechanism of BSFM in the cyclophosphamide-induced immunosuppressive mice model. The findings revealed that BSFM could significantly increase white blood cells (WBC) in peripheral blood; upregulate the expression of IL-4, TNF-α, and M-CSF in the plasma; and reduce tissue damage. Mechanistically, proteomics has revealed that BSFM therapy substantially affected the quantity of 29 proteins (Mtatp6, Cst3, Pglyrp1, Igkc, and other targets), which mostly participate in the phosphatidylcholine catabolic process, positive regulation of type IIa hypersensitivity, lipid catabolic process, and neutrophil chemotaxis. Metabolomics indicated that BSFM reduced the levels of Octanoylglucuronide, Gly-Gly, and N-alpha-acetyl-ornithine and modulated arginine biosynthesis. Furthermore, BSFM treatment modified the composition of gut microbiota and increased the relative abundance of Prevotella, S24-7, Olsenella, Lactococcus, hgcl-clade, Parasutterella, and Acetobacter. A significant correlation modified the composition of gut microbiota among inflammation-associated parameters, gut microbiota, and various metabolites (DMs) through Pearson correlation analysis. These findings suggest that BSFM holds promise in enhancing the human immune system and may serve as a complementary therapy in conventional chemotherapy.

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来源期刊
Food Science & Nutrition
Food Science & Nutrition Agricultural and Biological Sciences-Food Science
CiteScore
7.40
自引率
5.10%
发文量
434
审稿时长
24 weeks
期刊介绍: Food Science & Nutrition is the peer-reviewed journal for rapid dissemination of research in all areas of food science and nutrition. The Journal will consider submissions of quality papers describing the results of fundamental and applied research related to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.
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