揭示海角草副产物的营养潜力——胃肠道消化和肠道通透性对体外生物活性的影响

IF 9.8 1区 农林科学 Q1 CHEMISTRY, APPLIED
Diana Pinto , Inês Santos , Filipa Teixeira , Stefania Sut , Mónica Vieira , Miguel Salazar , Cristina Delerue-Matos , Stefano Dall'Acqua , Francisca Rodrigues
{"title":"揭示海角草副产物的营养潜力——胃肠道消化和肠道通透性对体外生物活性的影响","authors":"Diana Pinto ,&nbsp;Inês Santos ,&nbsp;Filipa Teixeira ,&nbsp;Stefania Sut ,&nbsp;Mónica Vieira ,&nbsp;Miguel Salazar ,&nbsp;Cristina Delerue-Matos ,&nbsp;Stefano Dall'Acqua ,&nbsp;Francisca Rodrigues","doi":"10.1016/j.foodchem.2025.144665","DOIUrl":null,"url":null,"abstract":"<div><div><em>Salicornia ramosissima</em> by-product (SP) is an underexploited antioxidant-rich by-product. This study explored the phytochemical profile, bioaccessibility, and biological activity of SP before and after extraction (SBE and SAE, respectively) upon gastrointestinal simulated digestion and intestinal permeability. The phenolic and flavonoid concentrations increased during digestion, reaching bioaccessibility rates above 95 % for both SBE and SAE. Promising antioxidant/antiradical properties and neuroprotective effects were attested upon digestion. Regarding the phytochemical profile, 17 compounds were identified, including (di)caffeoylquinic acids, gallocatechin, and triterpenoid saponins. The intestinal absorption of bioactive compounds from SAE and SBE intestinal digests was proven through a Caco-2/HT29-MTX cells co-culture model, with 4-caffeoylquinic acid (34.84 %) and 4,5-dicaffeoylquinic acid (26.73 %) reaching the highest permeation rates after 4 h, respectively, for SAE and SBE. These findings support the harnessing of SP as a promising functional and nutraceutical ingredient rich in pro-healthy compounds with proven bioactivity upon <em>in vitro</em> digestion and intestinal permeation.</div></div>","PeriodicalId":318,"journal":{"name":"Food Chemistry","volume":"486 ","pages":"Article 144665"},"PeriodicalIF":9.8000,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unraveling the nutraceutical potential of Salicornia ramosissima by-product – impact of gastrointestinal digestion and intestinal permeability on in vitro bioactivity\",\"authors\":\"Diana Pinto ,&nbsp;Inês Santos ,&nbsp;Filipa Teixeira ,&nbsp;Stefania Sut ,&nbsp;Mónica Vieira ,&nbsp;Miguel Salazar ,&nbsp;Cristina Delerue-Matos ,&nbsp;Stefano Dall'Acqua ,&nbsp;Francisca Rodrigues\",\"doi\":\"10.1016/j.foodchem.2025.144665\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div><em>Salicornia ramosissima</em> by-product (SP) is an underexploited antioxidant-rich by-product. This study explored the phytochemical profile, bioaccessibility, and biological activity of SP before and after extraction (SBE and SAE, respectively) upon gastrointestinal simulated digestion and intestinal permeability. The phenolic and flavonoid concentrations increased during digestion, reaching bioaccessibility rates above 95 % for both SBE and SAE. Promising antioxidant/antiradical properties and neuroprotective effects were attested upon digestion. Regarding the phytochemical profile, 17 compounds were identified, including (di)caffeoylquinic acids, gallocatechin, and triterpenoid saponins. The intestinal absorption of bioactive compounds from SAE and SBE intestinal digests was proven through a Caco-2/HT29-MTX cells co-culture model, with 4-caffeoylquinic acid (34.84 %) and 4,5-dicaffeoylquinic acid (26.73 %) reaching the highest permeation rates after 4 h, respectively, for SAE and SBE. These findings support the harnessing of SP as a promising functional and nutraceutical ingredient rich in pro-healthy compounds with proven bioactivity upon <em>in vitro</em> digestion and intestinal permeation.</div></div>\",\"PeriodicalId\":318,\"journal\":{\"name\":\"Food Chemistry\",\"volume\":\"486 \",\"pages\":\"Article 144665\"},\"PeriodicalIF\":9.8000,\"publicationDate\":\"2025-05-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Chemistry\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0308814625019168\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Chemistry","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0308814625019168","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0

摘要

水杨副产物(SP)是一种未被充分利用的富含抗氧化剂的副产物。本研究探讨了SP提取前后(分别为SBE和SAE)对胃肠道模拟消化和肠道通透性的植物化学特征、生物可及性和生物活性。在消化过程中,酚类和类黄酮浓度增加,SBE和SAE的生物可及性均达到95% %以上。有希望的抗氧化/抗自由基性能和神经保护作用证明了消化。在植物化学方面,鉴定出17种化合物,包括(二)咖啡酰奎宁酸、没食子儿茶素和三萜皂苷。通过Caco-2/HT29-MTX细胞共培养模型证实了SAE和SBE肠道消化液中生物活性化合物的肠道吸收,SAE和SBE在4 h后分别达到4-咖啡酰奎宁酸(34.84 %)和4,5-二咖啡酰奎宁酸(26.73 %)的最高渗透率。这些发现支持利用SP作为一种有前途的功能性和营养保健成分,富含有益健康的化合物,经体外消化和肠道渗透证实具有生物活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unraveling the nutraceutical potential of Salicornia ramosissima by-product – impact of gastrointestinal digestion and intestinal permeability on in vitro bioactivity
Salicornia ramosissima by-product (SP) is an underexploited antioxidant-rich by-product. This study explored the phytochemical profile, bioaccessibility, and biological activity of SP before and after extraction (SBE and SAE, respectively) upon gastrointestinal simulated digestion and intestinal permeability. The phenolic and flavonoid concentrations increased during digestion, reaching bioaccessibility rates above 95 % for both SBE and SAE. Promising antioxidant/antiradical properties and neuroprotective effects were attested upon digestion. Regarding the phytochemical profile, 17 compounds were identified, including (di)caffeoylquinic acids, gallocatechin, and triterpenoid saponins. The intestinal absorption of bioactive compounds from SAE and SBE intestinal digests was proven through a Caco-2/HT29-MTX cells co-culture model, with 4-caffeoylquinic acid (34.84 %) and 4,5-dicaffeoylquinic acid (26.73 %) reaching the highest permeation rates after 4 h, respectively, for SAE and SBE. These findings support the harnessing of SP as a promising functional and nutraceutical ingredient rich in pro-healthy compounds with proven bioactivity upon in vitro digestion and intestinal permeation.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Food Chemistry
Food Chemistry 工程技术-食品科技
CiteScore
16.30
自引率
10.20%
发文量
3130
审稿时长
122 days
期刊介绍: Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信