平行光纤半分布式生物传感器在飞摩尔极限下检测唾液中IL-6和IL-8癌症标志物

IF 4.6 2区物理与天体物理 Q1 OPTICS

Optics and Laser Technology Pub Date : 2025-05-07 DOI:10.1016/j.optlastec.2025.113139

Aida Zhakypbekova , Aliya Bekmurzayeva , Wilfried Blanc , Daniele Tosi

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引用次数: 0

摘要

基于生物标志物的诊断为早期癌症检测提供了一种很有前景的方法，同时分析多种生物标志物可以通过提高检测的敏感性和特异性进一步提高疾病诊断。本研究提出了一种多共振分析策略，用于同时检测人工唾液中白介素-6和白介素-8的生物标志物，该探针基于光纤布拉格光栅辅助半分布式干涉仪。传感器响应分析利用了全光谱特征，增强了检测结果的鲁棒性和可靠性。与单特征方法不同，多共振分析确保了对光谱扭曲的更大弹性，因为所提出的传感器的光谱特征对生物分子相互作用表现出不同的敏感性。该传感器对人工唾液中IL-6和IL-8的检测限（LoD）分别为480 aM和23.4 fM，对靶蛋白具有高特异性。

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Parallel fiber-optic semi-distributed biosensor for detection of IL-6 and IL-8 cancer biomarkers in saliva at femtomolar limit

Biomarker-based diagnostics offer a promising approach for early cancer detection, while simultaneous analysis of multiple biomarkers can further improve disease diagnosis by enhancing sensitivity and specificity of the detection. This work presents a multi-resonance analysis strategy for the simultaneous detection of oral cancer biomarkers interleukin-6 and interleukin-8 in artificial saliva with a Fiber-Bragg grating-assisted semi-distributed interferometer-based probe. The analysis of the sensor response takes advantage of the entire spectral feature, which enhances the robustness and reliability of the detection results. Unlike single-feature approaches, multi-resonance analysis ensures greater resilience to spectral distortions, since the spectral features of the proposed sensor exhibit varying sensitivity to biomolecular interactions. The sensor demonstrated a limit of detection (LoD) of 480 aM for IL-6 and 23.4 fM for IL-8 in artificial saliva with high specificity to target proteins.

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来源期刊

Optics and Laser Technology 物理-光学

CiteScore

8.50

自引率

10.00%

发文量

1060

审稿时长

3.4 months

期刊介绍： Optics & Laser Technology aims to provide a vehicle for the publication of a broad range of high quality research and review papers in those fields of scientific and engineering research appertaining to the development and application of the technology of optics and lasers. Papers describing original work in these areas are submitted to rigorous refereeing prior to acceptance for publication. The scope of Optics & Laser Technology encompasses, but is not restricted to, the following areas: •development in all types of lasers •developments in optoelectronic devices and photonics •developments in new photonics and optical concepts •developments in conventional optics, optical instruments and components •techniques of optical metrology, including interferometry and optical fibre sensors •LIDAR and other non-contact optical measurement techniques, including optical methods in heat and fluid flow •applications of lasers to materials processing, optical NDT display (including holography) and optical communication •research and development in the field of laser safety including studies of hazards resulting from the applications of lasers (laser safety, hazards of laser fume) •developments in optical computing and optical information processing •developments in new optical materials •developments in new optical characterization methods and techniques •developments in quantum optics •developments in light assisted micro and nanofabrication methods and techniques •developments in nanophotonics and biophotonics •developments in imaging processing and systems