强啡通过去抑制回路机制起作用

IF 34.7 1区医学 Q1 Neuroscience

Nature Reviews Neuroscience Pub Date : 2025-05-02 DOI:10.1038/s41583-025-00927-0

Jake Rogers

引用次数: 0

摘要

Dynorphin通过伏隔核-腹侧白球（VP）去抑制回路中的κ-阿片受体信号调节小鼠的动机行为，从而增加投射到杏仁核基底外侧的VP胆碱能神经元的活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Dynorphin acts via a disinhibitory circuit mechanism

Dynorphin regulates motivated behaviour in mice via κ-opioid receptor signalling in a nucleus accumbens–ventral pallidum (VP) disinhibitory circuit that increases activity of VP cholinergic neurons projecting to the basolateral amygdala.

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来源期刊

Nature Reviews Neuroscience 医学-神经科学

CiteScore

35.00

自引率

0.60%

发文量

104

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Neuroscience is a journal that is part of the Nature Reviews portfolio. It focuses on the multidisciplinary science of neuroscience, which aims to provide a complete understanding of the structure and function of the central nervous system. Advances in molecular, developmental, and cognitive neuroscience have made it possible to tackle longstanding neurobiological questions. However, the wealth of knowledge generated by these advancements has created a need for new tools to organize and communicate this information efficiently. Nature Reviews Neuroscience aims to fulfill this need by offering an authoritative, accessible, topical, and engaging resource for scientists interested in all aspects of neuroscience. The journal covers subjects such as cellular and molecular neuroscience, development of the nervous system, sensory and motor systems, behavior, regulatory systems, higher cognition and language, computational neuroscience, and disorders of the brain. Editorial decisions for the journal are made by a team of full-time professional editors who are PhD-level scientists.