强啡通过去抑制回路机制起作用

IF 26.7 1区医学 Q1 NEUROSCIENCES

Nature Reviews Neuroscience Pub Date : 2025-05-02 DOI:10.1038/s41583-025-00927-0

Jake Rogers

引用次数: 0

摘要

Dynorphin通过伏隔核-腹侧白球（VP）去抑制回路中的κ-阿片受体信号调节小鼠的动机行为，从而增加投射到杏仁核基底外侧的VP胆碱能神经元的活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Dynorphin acts via a disinhibitory circuit mechanism

Dynorphin regulates motivated behaviour in mice via κ-opioid receptor signalling in a nucleus accumbens–ventral pallidum (VP) disinhibitory circuit that increases activity of VP cholinergic neurons projecting to the basolateral amygdala.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nature Reviews Neuroscience NEUROSCIENCES-

自引率

0.60%

发文量

104

期刊介绍： Nature Reviews Neuroscience is a multidisciplinary journal that covers various fields within neuroscience, aiming to offer a comprehensive understanding of the structure and function of the central nervous system. Advances in molecular, developmental, and cognitive neuroscience, facilitated by powerful experimental techniques and theoretical approaches, have made enduring neurobiological questions more accessible. Nature Reviews Neuroscience serves as a reliable and accessible resource, addressing the breadth and depth of modern neuroscience. It acts as an authoritative and engaging reference for scientists interested in all aspects of neuroscience.