在饲料中添加C1 - C12单酰基甘油酯混合物可提高鸡对肠炎沙门氏菌感染的抵抗力

IF 3.8 1区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Poultry Science Pub Date : 2025-05-01 DOI:10.1016/j.psj.2025.105244

Marcela Faldynova , Jiri Volf , Daniela Karasova , Hana Prikrylova , Alena Sebkova , Adela Mullerova , Renata Kucerova , Sylvie Skalickova , Ivan Rychlik

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引用次数: 0

摘要

鸡是人类最重要的动物蛋白来源之一。然而，鸡也是人类沙门氏菌最重要的宿主之一。因此，不断寻求减少鸡中沙门氏菌发病率的措施。在本研究中，我们试验了添加C1至C12单酰基甘油酯混合物的饲料。在每吨饲料添加0.7和1.5 kg时，这种补充显著降低了盲肠中的沙门氏菌数量，但没有降低肝脏中的沙门氏菌数量。雏鸡在第4天感染，在出生后第22天和第23天记录其在盲肠中的保护作用。通过检测avidin、SAA、ExFABP、MMP7、IL1β、IL4I和MRP126基因的表达，添加饲料还降低了鸡对沙门氏菌感染的炎症反应，但不影响盲肠免疫球蛋白的表达。C1至C12单酰基甘油酯可以用作饲料补充剂，如果在饲料中持续添加，可以在屠宰前减少鸡的沙门氏菌计数。

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Feed supplementation with a mixture of C1 to C12 monoacylglycerides increases chicken resistance to Salmonella Enteritidis infection

Chickens represent one of the most important sources of animal protein for the human population. However, chickens also represent one of the most important reservoirs of Salmonella for humans. Measures to decrease the Salmonella incidence in chickens are therefore continuously sought. In this study, we tested feed supplementation with a mixture of C1 to C12 monoacylglycerides. At 0.7 and 1.5 kg per ton of feed, such supplementation significantly decreased Salmonella counts in the caecum but not in the liver. The chickens were infected on day 4 and the protective effect in the caecum was recorded on day 22 and 23 of life. Supplementation also decreased the inflammatory response of chickens to Salmonella infection determined by avidin, SAA, ExFABP, MMP7, IL1β, IL4I and MRP126 gene expression but did not affect immunoglobulin expression in the caecum. C1 to C12 monoacylglycerides can be used as a feed supplement which, if continuously provided in feed, decrease Salmonella counts in chickens just prior slaughter.

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来源期刊

Poultry Science 农林科学-奶制品与动物科学

CiteScore

7.60

自引率

15.90%

发文量

审稿时长

94 days

期刊介绍： First self-published in 1921, Poultry Science is an internationally renowned monthly journal, known as the authoritative source for a broad range of poultry information and high-caliber research. The journal plays a pivotal role in the dissemination of preeminent poultry-related knowledge across all disciplines. As of January 2020, Poultry Science will become an Open Access journal with no subscription charges, meaning authors who publish here can make their research immediately, permanently, and freely accessible worldwide while retaining copyright to their work. Papers submitted for publication after October 1, 2019 will be published as Open Access papers. An international journal, Poultry Science publishes original papers, research notes, symposium papers, and reviews of basic science as applied to poultry. This authoritative source of poultry information is consistently ranked by ISI Impact Factor as one of the top 10 agriculture, dairy and animal science journals to deliver high-caliber research. Currently it is the highest-ranked (by Impact Factor and Eigenfactor) journal dedicated to publishing poultry research. Subject areas include breeding, genetics, education, production, management, environment, health, behavior, welfare, immunology, molecular biology, metabolism, nutrition, physiology, reproduction, processing, and products.