维数减少简化了嗅觉回路中突触伙伴的匹配

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-05-01

Cheng Lyu, Zhuoran Li, Chuanyun Xu, Kenneth Kin Lam Wong, David J. Luginbuhl, Colleen N. McLaughlin, Qijing Xie, Tongchao Li, Hongjie Li, Liqun Luo

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引用次数: 0

摘要

导航轴突在三维空间中选择突触后伙伴时面临着复杂的选择。在这项工作中，我们发现了一个原理，可以通过将高维序列降低到1D投影来建立果蝇触角叶的3D肾小球图。在发育过程中，嗅觉受体神经元（ORN）轴突首先与触角叶球面上的同伴投射神经元树突接触，无论成年肾小球是靠近表面还是在内部。沿着这个二维表面，每种ORN类型的轴突都有一个特定的弧形轨迹，与它们的伴侣树突精确相交。改变轴突轨迹会影响突触伙伴的匹配。因此，3D搜索被简化为一维，简化了伙伴匹配。

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Dimensionality reduction simplifies synaptic partner matching in an olfactory circuit

A navigating axon faces complex choices when selecting postsynaptic partners in a three-dimensional (3D) space. In this work, we discovered a principle that can establish the 3D glomerular map of the fly antennal lobe by reducing the higher dimensionality serially to 1D projections. During development, olfactory receptor neuron (ORN) axons first contact their partner projection neuron dendrites on the spherical surface of the antennal lobe, regardless of whether the adult glomeruli lie near the surface or inside. Along this 2D surface, axons of each ORN type take a specific, arc-shaped trajectory that precisely intersects with their partner dendrites. Altering axon trajectories compromises synaptic partner matching. A 3D search is thus reduced to one dimension, simplifying partner matching.

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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