脂滴：与年龄相关的代谢疾病的新治疗靶点

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-04-27 DOI:10.1016/j.arr.2025.102758

Zheying Ma , Shou Pan , Yaming Yang , Huiqian Ren , Sikun Yin , Qianyu Chen , Zhenxian An , Xiaoqin Zhao , Zujie Xu

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引用次数: 0

摘要

脂质代谢在调节衰老和代谢疾病中起着至关重要的作用。脂滴（ld）是动态的、复杂的细胞器，负责中性脂质的储存和释放，对维持脂质稳态和能量代谢至关重要。衰老加速ld的积累、功能退化和代谢紊乱，从而诱发与年龄相关的代谢疾病（ARMDs）。本文回顾了已发表的ld与ARMDs之间关联的数据集，重点关注ld的结构和功能，它们与其他细胞器和相关蛋白的相互作用。此外，我们探讨了ld介导ARMDs发病的潜在机制，包括阿尔茨海默病（AD）、肌肉减少症、代谢性心肌病、非酒精性脂肪性肝病（NAFLD）和癌症。最后，我们讨论了针对ld的干预策略，包括运动、饮食和药物干预，以改善ARMDs的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Lipid droplets: Emerging therapeutic targets for age-related metabolic diseases

Lipids metabolism is crucial in regulating aging and metabolic diseases. Lipid droplets (LDs) are dynamic, complex organelles responsible for the storage and release of neutral lipids, essential for maintaining lipid homeostasis and energy metabolism. Aging accelerates the accumulation of LDs, functional deterioration, and metabolic disorders, thereby inducing age-related metabolic diseases (ARMDs). This review examines published datasets on the association between LDs and ARMDs, focusing on the structure and function of LDs, their interactions with other organelles, and associated proteins. Furthermore, we explore the potential mechanisms by which LDs mediate the onset of ARMDs, including Alzheimer’s disease (AD), sarcopenia, metabolic cardiomyopathy, non-alcoholic fatty liver disease (NAFLD), and cancer. Lastly, we discuss intervention strategies aimed at targeting LDs to improve outcomes in ARMDs, including exercise, dietary, and pharmacological interventions.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.