治疗代谢性骨病的口腔生物材料研究进展

IF 33.6 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Progress in Materials Science Pub Date : 2025-04-25 DOI:10.1016/j.pmatsci.2025.101499

Yunkai Tang, Adilijiang Abudousu, Wenguo Cui

{"title":"治疗代谢性骨病的口腔生物材料研究进展","authors":"Yunkai Tang, Adilijiang Abudousu, Wenguo Cui","doi":"10.1016/j.pmatsci.2025.101499","DOIUrl":null,"url":null,"abstract":"<div><div>Traditional drugs and their delivery methods still have their limitations in the treatment of many diseases. With the development and progress of materials science, new oral drug delivery systems are increasingly displaying their unique value in the treatment of many diseases because of their safety, high efficiency, tissue targeting, and controlled release. As a common clinical disease with high morbidity and complications, metabolic bone disease has become the focus of research because of its special pathophysiology and the limitations of existing treatment methods. In recent years, the use of biologically intelligent materials as novel oral delivery carriers has significantly enhanced the therapeutic effect in metabolic bone diseases. Based on the detailed discussion of the pathogenesis of metabolic bone diseases and various types of oral drug delivery systems based on biomaterials, this review expounds the medical applications in metabolic bone diseases and related mechanisms and deeply discusses the current challenges, development prospects, and clinical transformation opportunities of this new drug delivery material. This work aims to inspire further research into diversified biomedical applications of oral biomaterials.</div></div>","PeriodicalId":411,"journal":{"name":"Progress in Materials Science","volume":"153 ","pages":"Article 101499"},"PeriodicalIF":33.6000,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Progress in oral biomaterials for the treatment of metabolic bone diseases\",\"authors\":\"Yunkai Tang, Adilijiang Abudousu, Wenguo Cui\",\"doi\":\"10.1016/j.pmatsci.2025.101499\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Traditional drugs and their delivery methods still have their limitations in the treatment of many diseases. With the development and progress of materials science, new oral drug delivery systems are increasingly displaying their unique value in the treatment of many diseases because of their safety, high efficiency, tissue targeting, and controlled release. As a common clinical disease with high morbidity and complications, metabolic bone disease has become the focus of research because of its special pathophysiology and the limitations of existing treatment methods. In recent years, the use of biologically intelligent materials as novel oral delivery carriers has significantly enhanced the therapeutic effect in metabolic bone diseases. Based on the detailed discussion of the pathogenesis of metabolic bone diseases and various types of oral drug delivery systems based on biomaterials, this review expounds the medical applications in metabolic bone diseases and related mechanisms and deeply discusses the current challenges, development prospects, and clinical transformation opportunities of this new drug delivery material. This work aims to inspire further research into diversified biomedical applications of oral biomaterials.</div></div>\",\"PeriodicalId\":411,\"journal\":{\"name\":\"Progress in Materials Science\",\"volume\":\"153 \",\"pages\":\"Article 101499\"},\"PeriodicalIF\":33.6000,\"publicationDate\":\"2025-04-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in Materials Science\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0079642525000775\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in Materials Science","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0079642525000775","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

传统药物及其给药方法在许多疾病的治疗中仍有其局限性。随着材料科学的发展和进步，新型口服给药系统以其安全性、高效性、组织靶向性和控释性等优点，在多种疾病的治疗中越来越显示出其独特的价值。代谢性骨病作为一种常见的高发病率、高并发症的临床疾病，由于其特殊的病理生理特点和现有治疗方法的局限性，已成为研究的热点。近年来，利用生物智能材料作为新型口服给药载体，显著提高了代谢性骨病的治疗效果。本文在详细论述代谢性骨病发病机制和各类基于生物材料的口服给药系统的基础上，阐述了代谢性骨病的医学应用及其相关机制，并深入探讨了这种新型给药材料目前面临的挑战、发展前景和临床转化机遇。本研究旨在为进一步研究口腔生物材料在生物医学领域的多样化应用提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Progress in oral biomaterials for the treatment of metabolic bone diseases

Traditional drugs and their delivery methods still have their limitations in the treatment of many diseases. With the development and progress of materials science, new oral drug delivery systems are increasingly displaying their unique value in the treatment of many diseases because of their safety, high efficiency, tissue targeting, and controlled release. As a common clinical disease with high morbidity and complications, metabolic bone disease has become the focus of research because of its special pathophysiology and the limitations of existing treatment methods. In recent years, the use of biologically intelligent materials as novel oral delivery carriers has significantly enhanced the therapeutic effect in metabolic bone diseases. Based on the detailed discussion of the pathogenesis of metabolic bone diseases and various types of oral drug delivery systems based on biomaterials, this review expounds the medical applications in metabolic bone diseases and related mechanisms and deeply discusses the current challenges, development prospects, and clinical transformation opportunities of this new drug delivery material. This work aims to inspire further research into diversified biomedical applications of oral biomaterials.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Progress in Materials Science 工程技术-材料科学：综合

CiteScore

59.60

自引率

0.80%

发文量

101

审稿时长

11.4 months

期刊介绍： Progress in Materials Science is a journal that publishes authoritative and critical reviews of recent advances in the science of materials. The focus of the journal is on the fundamental aspects of materials science, particularly those concerning microstructure and nanostructure and their relationship to properties. Emphasis is also placed on the thermodynamics, kinetics, mechanisms, and modeling of processes within materials, as well as the understanding of material properties in engineering and other applications. The journal welcomes reviews from authors who are active leaders in the field of materials science and have a strong scientific track record. Materials of interest include metallic, ceramic, polymeric, biological, medical, and composite materials in all forms. Manuscripts submitted to Progress in Materials Science are generally longer than those found in other research journals. While the focus is on invited reviews, interested authors may submit a proposal for consideration. Non-invited manuscripts are required to be preceded by the submission of a proposal. Authors publishing in Progress in Materials Science have the option to publish their research via subscription or open access. Open access publication requires the author or research funder to meet a publication fee (APC). Abstracting and indexing services for Progress in Materials Science include Current Contents, Science Citation Index Expanded, Materials Science Citation Index, Chemical Abstracts, Engineering Index, INSPEC, and Scopus.