Formulation and Characterization of Multi-Source Edible Oils From Groundnut and African Walnuts Oils and Their Effect on Some Biochemical Parameters of High Fat Diet Induced Obese Wistar Rats

This study aimed at evaluating the effect of multi-source edible oils from groundnut and African walnut oils in the management of obesity in high fat diet induced-obese Wistar rats. Groundnut oil (GO), African walnut oil (WO), and their 50:50 and 60:40 blends (GO:WO) were used and tested for their quality. For the in vivo part, 42 albino Wistar rats were used. They were divided into 7 groups containing 6 rats each. Group 1 received the normal diet and groups 2 to 7 the high-fat diet for 60 days. Group 3 was treated with orlistat, and groups 4–7 with oils for 28 days. The rats were sacrificed and the sera prepared from the blood which were used for biochemical analyses (lipid profile and serum enzymes). Results showed that the oils used had good quality. The oils significantly (p < 0.05) decreased the serum lipids (except for HDL which increased), total cholesterol/HDL ratios, and the atherogenic index. Aspartate aminotransferase (ASP) and creatinine were significantly decreased (p < 0.05) in treated and normal groups. For alanine aminotransferase (ALT) levels, the normal group and those treated with orlistat and GO presented the lowest (p < 0.05) concentrations. GO, WO, and their blends can be recommended as food ingredient for obese patients.