凝固芽孢杆菌BC99保护电离辐射引起的小鼠肠道损伤并调节肠道微生物群和代谢物

IF 4.5 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Molecular Nutrition & Food Research Pub Date : 2025-04-17 DOI:10.1002/mnfr.70057

Lin-Feng Tang, Feng-Ling Tang, Hao Zhou, Ze-Kun Li, Chao-Qun Pi, Yang He, Ming Li

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引用次数: 0

摘要

胃肠道对电离辐射（IR）高度敏感，可引起辐射性肠损伤（RIII）。临床常规治疗中没有针对RIII的有效药物，这是骨盆腹部恶性肿瘤放疗过程中的主要限制因素。在本研究中，我们旨在阐明益生菌Bacillus coagulans BC99 （b.c coagulans BC99）预防RIII的潜力。给C57BL/6J小鼠灌胃凝固芽孢杆菌BC99 30 d，然后进行单剂量12 Gy x线全腹照射（WAI）。治疗B.coagulans BC99可通过预防体重减轻、维持肠道结构和屏障的完整性、改善炎症症状、调节氧化应激、调节肠道菌群组成，从而重建肠道内稳态，从而减轻RIII。此外，凝血芽孢杆菌BC99潜在的辐射防护机制与肠道微生物衍生代谢物密切相关。本研究为推进益生菌治疗RIII和加强RIII的预防策略提供了新的视角。

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Bacillus Coagulans BC99 Protects Ionizing Radiation-Induced Intestinal Injury and Modulates Gut Microbiota and Metabolites in Mice

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Bacillus Coagulans BC99 Protects Ionizing Radiation-Induced Intestinal Injury and Modulates Gut Microbiota and Metabolites in Mice

The gastrointestinal tract is highly sensitive to ionizing radiation (IR), which causes radiation-induced intestinal injury (RIII). There are no effective drugs available for RIII in routine clinical treatment, which is a major limiting factor during the process of radiotherapy for pelvic abdominal malignancies. In this study, we aimed to elucidate the potential of probiotic Bacillus coagulans BC99 (B.coagulans BC99) in preventing RIII. C57BL/6J mice were gavage-administered with B.coagulans BC99 for 30 days and then exposed to a single dose of 12 Gy x-ray whole abdominal irradiation (WAI). B.coagulans BC99 treatment could mitigate RIII by preventing weight loss, maintaining the integrity of intestinal structure and barrier, improving inflammatory symptoms, modulating oxidative stress, and regulating the composition of gut microbiota, thereby reestablishing intestinal homeostasis. In addition, the potential radioprotective mechanism of B.coagulans BC99 was closely related to the gut microbiota-derived metabolites. This study offers a novel perspective for advancing probiotic-based treatments for RIII and enhancing strategies for the prevention of RIII.

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来源期刊

Molecular Nutrition & Food Research 工程技术-食品科技

CiteScore

8.70

自引率

1.90%

发文量

250

审稿时长

1.7 months

期刊介绍： Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.