EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López-Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto-Maradona, Ilen Röhe, Katerina Theodoridou, Maria de Lourdes Bastos, Paul Brantom, Andrew Chesson, Josef Schlatter, Johannes Westendorf, Maria Dulak-Lis, Paola Manini
{"title":"饲料添加剂反式茴香醚和丁香酚在所有禽类中使用的安全性和有效性(ADISSEO、ADM、AGOLIN(爱尔兰)有限公司、嘉吉、帝斯曼营养产品有限公司、LABORATORIES PHODE、Norel S.A.)","authors":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López-Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto-Maradona, Ilen Röhe, Katerina Theodoridou, Maria de Lourdes Bastos, Paul Brantom, Andrew Chesson, Josef Schlatter, Johannes Westendorf, Maria Dulak-Lis, Paola Manini","doi":"10.2903/j.efsa.2025.9367","DOIUrl":null,"url":null,"abstract":"<p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of 1-methoxy-4-(prop-1-(<i>trans</i>)-enyl)benzene (<i>trans</i>-anethole) and eugenol as sensory feed additives for all avian species. The additives are already authorised for use in all animal species except fish and poultry. The additives under assessment, <i>trans</i>-anethole (from either chemical synthesis or natural origin) and eugenol of natural origin, are considered of no safety concern for species (chickens and turkeys) for fattening and of being very unlikely to induce adverse effects in long-living and reproductive animals (laying hens) up to the maximum proposed use levels of 25 mg/kg complete feed. These conclusions are extrapolated to physiologically-related minor species. No safety concern would be expected for the consumer of animal products from the use of <i>trans</i>-anethole and eugenol up to the maximum proposed use level in feed. The use of <i>trans</i>-anethole and eugenol as feed additives is considered safe for the environment. Regarding user safety, <i>trans</i>-anethole is not irritant to skin and eyes but is a dermal sensitiser. Eugenol is irritant to skin and eyes and is a dermal sensitiser. When handling <i>trans</i>-anethole or eugenol, exposure of unprotected users to estragole or methyleugenol may occur. Therefore, to reduce the risk, the exposure of the users should be minimised. Since <i>trans</i>-anethole and eugenol are used in food as flavourings, and their function in feed is essentially the same as that in food, no further demonstration of efficacy is necessary.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"23 4","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9367","citationCount":"0","resultStr":"{\"title\":\"Safety and efficacy of the feed additives trans-anethole and eugenol for use in all avian species (ADISSEO, ADM, AGOLIN (Ireland) Ltd, Cargill, DSM Nutritional Products Ltd., LABORATORIES PHODE, Norel S.A.)\",\"authors\":\"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López-Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto-Maradona, Ilen Röhe, Katerina Theodoridou, Maria de Lourdes Bastos, Paul Brantom, Andrew Chesson, Josef Schlatter, Johannes Westendorf, Maria Dulak-Lis, Paola Manini\",\"doi\":\"10.2903/j.efsa.2025.9367\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of 1-methoxy-4-(prop-1-(<i>trans</i>)-enyl)benzene (<i>trans</i>-anethole) and eugenol as sensory feed additives for all avian species. The additives are already authorised for use in all animal species except fish and poultry. The additives under assessment, <i>trans</i>-anethole (from either chemical synthesis or natural origin) and eugenol of natural origin, are considered of no safety concern for species (chickens and turkeys) for fattening and of being very unlikely to induce adverse effects in long-living and reproductive animals (laying hens) up to the maximum proposed use levels of 25 mg/kg complete feed. These conclusions are extrapolated to physiologically-related minor species. No safety concern would be expected for the consumer of animal products from the use of <i>trans</i>-anethole and eugenol up to the maximum proposed use level in feed. The use of <i>trans</i>-anethole and eugenol as feed additives is considered safe for the environment. Regarding user safety, <i>trans</i>-anethole is not irritant to skin and eyes but is a dermal sensitiser. Eugenol is irritant to skin and eyes and is a dermal sensitiser. When handling <i>trans</i>-anethole or eugenol, exposure of unprotected users to estragole or methyleugenol may occur. Therefore, to reduce the risk, the exposure of the users should be minimised. Since <i>trans</i>-anethole and eugenol are used in food as flavourings, and their function in feed is essentially the same as that in food, no further demonstration of efficacy is necessary.</p>\",\"PeriodicalId\":11657,\"journal\":{\"name\":\"EFSA Journal\",\"volume\":\"23 4\",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-04-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9367\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"EFSA Journal\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2025.9367\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"EFSA Journal","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2025.9367","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Safety and efficacy of the feed additives trans-anethole and eugenol for use in all avian species (ADISSEO, ADM, AGOLIN (Ireland) Ltd, Cargill, DSM Nutritional Products Ltd., LABORATORIES PHODE, Norel S.A.)
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of 1-methoxy-4-(prop-1-(trans)-enyl)benzene (trans-anethole) and eugenol as sensory feed additives for all avian species. The additives are already authorised for use in all animal species except fish and poultry. The additives under assessment, trans-anethole (from either chemical synthesis or natural origin) and eugenol of natural origin, are considered of no safety concern for species (chickens and turkeys) for fattening and of being very unlikely to induce adverse effects in long-living and reproductive animals (laying hens) up to the maximum proposed use levels of 25 mg/kg complete feed. These conclusions are extrapolated to physiologically-related minor species. No safety concern would be expected for the consumer of animal products from the use of trans-anethole and eugenol up to the maximum proposed use level in feed. The use of trans-anethole and eugenol as feed additives is considered safe for the environment. Regarding user safety, trans-anethole is not irritant to skin and eyes but is a dermal sensitiser. Eugenol is irritant to skin and eyes and is a dermal sensitiser. When handling trans-anethole or eugenol, exposure of unprotected users to estragole or methyleugenol may occur. Therefore, to reduce the risk, the exposure of the users should be minimised. Since trans-anethole and eugenol are used in food as flavourings, and their function in feed is essentially the same as that in food, no further demonstration of efficacy is necessary.
期刊介绍:
The EFSA Journal covers methods of risk assessment, reports on data collected, and risk assessments in the individual areas of plant health, plant protection products and their residues, genetically modified organisms, additives and products or substances used in animal feed, animal health and welfare, biological hazards including BSE/TSE, contaminants in the food chain, food contact materials, enzymes, flavourings and processing aids, food additives and nutrient sources added to food, dietetic products, nutrition and allergies.