[11]ER176在TSPO基因型中与tau共定位的脑炎症图像。

IF 14.6 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2025-04-04 DOI:10.1016/j.tins.2025.03.005

Aisling M Chaney, Brian A Gordon

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引用次数: 0

摘要

由于炎症过程在神经变性中的作用，准确测量阿尔茨海默病（AD）的脑部炎症至关重要。在最近的一项研究中，Appleton、Finn 等人利用新型转运蛋白 18 kDa（TSPO）--正电子发射断层扫描（PET）示踪剂 [11C]ER176 克服了基因型相关的结合问题，显示了早发性 AD 中炎症的增加，其模式与 tau 病理学的关系比淀粉样蛋白沉积或萎缩更为密切。

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[¹¹C]ER176 images brain inflammation across TSPO genotypes and colocalizes with tau.

Accurately measuring brain inflammation in Alzheimer's disease (AD) is crucial due to the role of inflammatory processes in neurodegeneration. In a recent study, Appleton, Finn, et al. used [¹¹C]ER176, a novel translocator protein 18 kDa (TSPO)-positron emission tomography (PET) tracer overcoming genotype-related binding issues, to show increased inflammation in early-onset AD, with patterns aligning more closely with tau pathology than amyloid deposition or atrophy.

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.