海洋脂溶性成分有效利用的分子营养研究。

IF 1.6 4区 农林科学 Q3 CHEMISTRY, APPLIED
Masashi Hosokawa
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引用次数: 0

摘要

海洋生物含有独特的脂溶性成分。因此,我们关注这些脂溶性成分的健康益处,并进行了分子营养研究。岩藻黄素(Fx)是一种典型的海洋类胡萝卜素,存在于裙带菜(裙带菜)和日本糖藻(马孔布)等棕色海藻中,我们在动物模型中证实了其抗肥胖和抗糖尿病的作用。研究发现,膳食Fx可激活糖尿病/肥胖KK-Ay小鼠骨骼肌中的胰岛素信号通路和葡萄糖转运蛋白4 (GLUT 4),是其抗糖尿病作用的分子机制。值得注意的是,Fx促进了比目鱼肌中GLUT4的易位,上调了EDL肌中GLUT4的表达,并通过不同肌肉类型的有效葡萄糖摄取来预防和改善高血糖。另一方面,n-3二十二碳五烯酸(n-3 DPA),一种在鲑鱼和鳟鱼中发现的n-3多不饱和脂肪酸,在培养细胞中转化为EPA和DHA。n- 3dpa的细胞内转化在巨噬细胞、肝脏和肠道细胞中存在差异。n- 3dpa显著下调活化巨噬细胞促炎因子mRNA表达。n- 3dpa对IL-6 mRNA表达的抑制作用与DHA相似,但强于EPA。此外,我们还证明了n-3 pufa结合的磷脂酰甘油(PG)对活化的巨噬细胞具有抗炎作用,并且其作用强于n-3 pufa -磷脂酰胆碱(PC)。此外,与n-3 PUFA-PC处理相比,n-3 PUFA-PG显著增加了细胞内EPA和DHA含量,并诱导Nrf2激活。n-3 PUFA-PG可增强细胞内PUFAs,存在于几种微藻中,如三角褐指藻。它也可以酶促制备,有望作为一种新的功能脂类。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular Nutritional Research for Effective Utilization of Marine Lipid-soluble Components.

Marine organisms contain unique lipid-soluble components. Therefore, we focused on the health benefits of these lipid-soluble components and conducted molecular nutritional studies. Fucoxanthin (Fx) is a typical marine carotenoid, found in brown seaweeds, such as Undaria pinnatifida (Wakame) and Saccharina japonica (Makonbu), and we demonstrated its anti-obesity and anti-diabetic effects in animal models. As the molecular mechanism for anti-diabetic effect, dietary Fx has found to activate insulin signaling pathways and glucose transporter 4 (GLUT 4) in the skeletal muscles of diabetic/obese KK-Ay mice. Notably, Fx promoted GLUT4 translocation in the soleus muscle, up-regulated GLUT4 expression in the EDL muscle, and prevented and improved hyperglycemia through effective glucose uptake depending on the muscle types. On the other hand, n-3 docosapentaenoic acid (n-3 DPA), an n-3 poly unsaturated fatty acid found in salmon and trout, is converted to EPA and DHA in cultured cells. The intracellular conversion of n-3 DPA differed different among cells derived from macrophages, liver, and intestines. n-3 DPA markedly down-regulates the mRNA expression of pro-inflammatory factors in activated macrophages. The suppressive effect of n-3 DPA on IL-6 mRNA expression was similar to that of DHA, but stronger than that of EPA. In addition, we demonstrated that n-3 PUFA-binding phosphatidylglycerol (PG) exhibited anti-inflammatory effects against activated macrophages, and that the effect was stronger than that of n-3 PUFA-phosphatidylcholine (PC). Furthermore, n-3 PUFA-PG significantly increased the intracellular EPA and DHA content compared to n-3 PUFA-PC treatment and induced Nrf2 activation. n-3 PUFA-PG, which enhances intracellular PUFAs, is contained in several microalgae such as Phaeodactylum tricornutum. It can also be enzymatically prepared and is expected to be used as a new functional lipid.

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来源期刊
Journal of oleo science
Journal of oleo science CHEMISTRY, APPLIED-FOOD SCIENCE & TECHNOLOGY
CiteScore
3.20
自引率
6.70%
发文量
173
审稿时长
3 months
期刊介绍: The J. Oleo Sci. publishes original researches of high quality on chemistry, biochemistry and science of fats and oils such as related food products, detergents, natural products, petroleum products, lipids and related proteins and sugars. The Journal also encourages papers on chemistry and/or biochemistry as a major component combined with biological/ sensory/nutritional/toxicological evaluation related to agriculture and/or food.
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