静态和动态压缩下压电骨和骨细胞的力电效应的仿真研究。

IF 1.7 4区医学 Q3 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-04-01 DOI:10.1080/10255842.2025.2484562

Zhu Wang, Haiying Liu, Hanqing Zhao, Chunqiu Zhang

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引用次数: 0

摘要

本文分析了考虑骨在静、动态压缩下的压电效应的流动电位（SP）的产生规律。在SP方程中引入压电方程，利用COMSOL软件建立骨细胞与骨细胞的三维流固耦合有限元模型。7种工况有助于对SP的研究。结果显示，动态负荷下，SP阳性与阴性交替作用于骨细胞，且SP比静态负荷下的作用高约3个数量级。因此，动态载荷改善了骨细胞的力电微环境。力电效应揭示了骨质疏松症的治疗机制。

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Simulation study on the force-electric effect of piezoelectric bone and osteocytes under static and dynamic compression.

This study analyzed the generation rule of streaming potential (SP) considering the piezoelectric effect of bone under static and dynamic compression. The piezoelectric equation was introduced into the equation of SP, and an osteon's 3D fluid-structure interaction finite element model with osteocytes was developed using COMSOL software. Seven working conditions helped study SP. The results showed positive and negative SP alternately acted on osteocyte under dynamic loads, and SP was about three orders of magnitude higher than that under static loads. Therefore, dynamic loads improved the osteocytes' force-electric microenvironment. The force-electric effect revealed the mechanism of treatment of osteoporosis.

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来源期刊

Computer Methods in Biomechanics and Biomedical Engineering 工程技术-工程：生物医学

CiteScore

4.10

自引率

6.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： The primary aims of Computer Methods in Biomechanics and Biomedical Engineering are to provide a means of communicating the advances being made in the areas of biomechanics and biomedical engineering and to stimulate interest in the continually emerging computer based technologies which are being applied in these multidisciplinary subjects. Computer Methods in Biomechanics and Biomedical Engineering will also provide a focus for the importance of integrating the disciplines of engineering with medical technology and clinical expertise. Such integration will have a major impact on health care in the future.