日本食品添加剂风险评估修订指南》。

Food safety (Tokyo, Japan) Pub Date : 2025-03-21 eCollection Date: 2025-03-01 DOI:10.14252/foodsafetyfscj.D-24-00018
Takahiro Inoue, Daisuke Ikeda, Maako Sugiyama, Asami Suenaga, Minoru Kawashima, Emiko Kondo, Takashi Umemura
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摘要

2021年9月,日本食品安全委员会(FSCJ)修订了2010年食品添加剂风险评估指南。修订后的指南题为《食品添加剂风险评估指南》,纳入了毒性测试的最新国际趋势,并反映了从以前的评估中获得的经验。修订后的指南包括以下四章:第一章。一般规定;第二章。详细阐述;第三章。加工助剂风险评估方法;第四章。4个月以下婴儿用作母乳代用品的食品中添加剂风险评估方法。修订指南的一个中心特点是将风险评估分为四个不同的步骤:危害识别、危害特征(毒理学评估)、暴露评估和风险特征。这些步骤以食品法典原则为基础,确保对食品添加剂进行全面和系统的评估。该指南还介绍了加工助剂的毒理学关注阈值(TTC)方法,以及评估四个月以下婴儿用作母乳代用品的添加剂的指南,考虑到它们的具体特点。本文概述了这些关键的更新,并提供了一个结构化的方法,以提高透明度和一致性的食品添加剂风险评估实践在日本。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Revised Guidelines for the Risk Assessment of Food Additives in Japan.

In September 2021, the Food Safety Commission of Japan (FSCJ) revised its 2010 guidelines for the risk assessment of food additives. The revised guidelines, titled Guidelines for the Risk Assessment of Food Additives, incorporate updated international trends in toxicity testing and reflect the experience gained from prior assessments. The revised guidelines are composed of the following 4 chapters: Chapter 1. General Provisions; Chapter 2. Detailed Exposition; Chapter 3. Approach for the risk assessment of processing aids; and Chapter 4. Approach for the risk assessment of additives in foods used as breast milk substitutes for infants under four months old. A central feature of the revised guidelines is the organization of risk assessment into four distinct steps: hazard identification, hazard characterization (toxicological assessment), exposure assessment, and risk characterization. These steps, based on the Codex Alimentarius principles, ensure a thorough and systematic evaluation of food additives. The guidelines also introduce the Threshold of Toxicological Concern (TTC) approach for processing aids and guideline for assessing the additives used as breast milk substitutes for infants under four months old, considering their specific characteristics. This paper provides an overview of these key updates, and offer a structured approach to enhance transparency and consistency risk assessment practices for food additives in Japan.

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