Vocal Feature Changes for Monitoring Parkinson's Disease Progression-A Systematic Review.

Background: Parkinson's disease has a significant impact on vocal characteristics and speech patterns, making them potential biomarkers for monitoring disease progression. To effectively utilise these biomarkers, it is essential to understand how they evolve over time as this degenerative disease progresses. Objectives: This review aims to identify the most used vocal features in Parkinson's disease monitoring and to track the temporal changes observed in each feature. Methods: An online database search was conducted to identify studies on voice and speech changes associated with Parkinson's disease progression. The analysis examined the features and their temporal changes to identify potential feature classes and trends. Results: Eighteen features were identified and categorised into three main aspects of speech: articulation, phonation and prosody. While twelve of these features exhibited measurable variations in Parkinsonian voices compared to those of healthy individuals, insights into long-term changes were limited. Conclusions: Vocal features can effectively discriminate Parkinsonian voices and may be used to monitor changes through disease progression. These changes remain underexplored and necessitate more evidence from long-term studies. The additional evidence could provide clinical insights into the disease and enhance the effectiveness of automated voice-based monitoring.