多系统萎缩中脑脊液和血液中的神经丝轻链:系统回顾和荟萃分析。

IF 2.7 3区 医学 Q3 NEUROSCIENCES
Silvia Demiri, Dimitra Veltsista, Vasileios Siokas, Kanellos C Spiliopoulos, Antonia Tsika, Polyxeni Stamati, Elisabeth Chroni, Efthimios Dardiotis, Ioannis Liampas
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引用次数: 0

摘要

背景/目的:多系统萎缩(MSA)由于其临床与其他神经退行性疾病,特别是其他α-突触核蛋白病重叠,因此诊断具有挑战性。本系统综述和荟萃分析的主要目的是评估MSA患者与健康对照组(HC)、帕金森病(PD)和路易体痴呆(LBD)患者脑脊液和血液中神经丝轻链(NfL)的差异。其次,讨论了CSF和循环NfL在MSA与HC、PD、LBD、进行性核上性麻痹(PSP)和皮质基底变性(CBD)的诊断指标。方法:全面检索MEDLINE和EMBASE相关病例对照研究。每次比较分别计算CSF和血NfL的标准化平均差异(SMDs)。根据Q和I^2统计量评估统计异质性。结果:共检索到25项相关研究。定量合成显示,MSA与HC [SMD = 1.80 (95%CI = 1.66, 1.94)和SMD = 2.00 (95%CI = 1.36, 2.63)]相比,PD [SMD = 1.65 (95%CI = 1.26, 2.03)和SMD = 1.63 (95%CI = 0.84, 2.43)]以及LBD [SMD = 1.17, (95%CI = 0.71, 1.63)和SMD = 0.65 (95%CI = 0.30, 1.00)]患者脑脊液和循环NfL水平升高。MSA对HC和PD的脑脊液和血液NfL的诊断准确性突出,MSA对LBD的诊断准确性中等。另一方面,与PSP和CBD相比,MSA是次优的。结论:与HC、PD和LBD相比,MSA患者的CSF和循环NfL水平均升高。为了获得最佳的诊断特性,需要在标准化流程和建立参考NfL区间和/或阈值方面做进一步的工作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neurofilament Light Chain in Cerebrospinal Fluid and Blood in Multiple System Atrophy: A Systematic Review and Meta-Analysis.

Background/Objectives: Multiple system atrophy (MSA) presents a challenging diagnosis due to its clinical overlap with other neurodegenerative disorders, especially other α-synucleinopathies. The main purpose of this systematic review and meta-analysis was to assess neurofilament light chain (NfL) differences in the CSF and blood of patients with MSA versus the healthy control group (HC), patients with Parkinson's disease (PD) and patients with Lewy body dementia (LBD). Secondarily, the diagnostic metrics of CSF and circulating NfL in MSA versus HC, PD, LBD, progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) were discussed. Methods: MEDLINE and EMBASE were thoroughly searched for relevant case-control studies. Standardized mean differences (SMDs) were calculated separately for CSF and blood NfL per comparison. Statistical heterogeneity was assessed based on the Q and I^2 statistics. Results: Twenty-five relevant studies were retrieved. Quantitative syntheses revealed elevated CSF and circulating NfL levels in individuals with MSA versus HC [SMD = 1.80 (95%CI = 1.66, 1.94) and SMD = 2.00 (95%CI = 1.36, 2.63), respectively] versus PD [SMD = 1.65 (95%CI = 1.26, 2.03) and SMD = 1.63 (95%CI = 0.84, 2.43), respectively] as well as versus LBD [SMD = 1.17, (95%CI = 0.71, 1.63) and SMD = 0.65 (95%CI = 0.30, 1.00), respectively]. Diagnostic accuracy was outstanding for CSF and blood NfL in MSA versus HC and PD, and it was moderate in MSA versus LBD. On the other hand, it was suboptimal in MSA vs. PSP and CBD. Conclusions: Both CSF and circulating NfL levels are elevated in MSA compared to HC, PD and LBD. To achieve optimal diagnostic properties, further work is required in the standardization of processes and the establishment of reference NfL intervals and/or thresholds.

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来源期刊
Brain Sciences
Brain Sciences Neuroscience-General Neuroscience
CiteScore
4.80
自引率
9.10%
发文量
1472
审稿时长
18.71 days
期刊介绍: Brain Sciences (ISSN 2076-3425) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications in the areas of cognitive neuroscience, developmental neuroscience, molecular and cellular neuroscience, neural engineering, neuroimaging, neurolinguistics, neuropathy, systems neuroscience, and theoretical and computational neuroscience. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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