柚皮素通过调节乙酰胆碱酯酶对二氮嗪致雄性白化大鼠小脑损伤的神经保护作用。

IF 2.7 3区 医学 Q3 NEUROSCIENCES
Abdullah A Saati
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引用次数: 0

摘要

背景:二嗪农是一种众所周知的有机磷化合物,主要通过抑制乙酰胆碱酯酶(AChE)和诱导氧化应激而具有神经毒性作用。目的:研究柑桔类黄酮柚皮素对二嗪醌诱导的雄性白化大鼠小脑损伤的保护作用。材料与方法:将24只大鼠分为4组:对照组、柚皮素组、重氮嗪酮组、柚皮素加重氮嗪酮组。结果:组织学检查显示,重嗪农组小鼠小脑浦肯野细胞结构发生改变。柚皮素共处理通过降低丙二醛(MDA)、增加谷胱甘肽(GSH)和谷胱甘肽过氧化物酶(GPx)水平,显著改善小脑组织结构,调节氧化应激标志物。柚皮素通过降低核因子-κB (NF-κB)、肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6)和白细胞介素-1β (IL-1β)水平,升高白细胞介素-10 (IL-10),表现出抗炎作用。它还降低了凋亡标志物,包括p53、Bax、caspase-9、caspase-8和caspase-3,同时增加了抗凋亡标志物Bcl-2。此外,柚皮素调节乙酰胆碱酯酶活性,导致乙酰胆碱水平降低和神经毒性降低。结论:柚皮素的抗氧化、抗炎和抗凋亡作用可能参与了其对重氮嗪壬致小脑损伤的神经保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Naringenin's Neuroprotective Effect on Diazino-Induced Cerebellar Damage in Male Albino Rats, with Modulation of Acetylcholinesterase.

Background: Diazinon, a well-known organophosphorus compound, is recognized for its neurotoxic effects, primarily through the inhibition of acetylcholinesterase (AChE) and induction of oxidative stress.

Aim: This study evaluates the neuroprotective effects of naringenin, a citrus flavonoid, against diazinon-induced cerebellar damage in male albino rats.

Materials and methods: Twenty-four rats were divided into four groups: control, naringenin, diazinon, and diazinon with naringenin.

Results: Histological examination revealed altered structures of Purkinje cells in the cerebellum of the diazinon group. Naringenin co-treatment significantly improved cerebellar histology and modulated oxidative stress markers by decreasing malondialdehyde (MDA) and increasing glutathione (GSH) and glutathione peroxidase (GPx) levels. Additionally, naringenin exhibited anti-inflammatory effects by decreasing nuclear factor-kappa B (NF-κB), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β) levels, while increasing interleukin-10 (IL-10). It also reduced apoptotic markers, including p53, Bax, caspase-9, caspase-8, and caspase-3, while increasing the anti-apoptotic marker Bcl-2. Furthermore, naringenin modulated AChE activity, leading to decreased acetylcholine levels and reduced neurotoxicity.

Conclusions: These findings suggest that naringenin's antioxidant, anti-inflammatory, and anti-apoptotic properties contribute to its neuroprotective role against diazinon-induced cerebellar damage.

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来源期刊
Brain Sciences
Brain Sciences Neuroscience-General Neuroscience
CiteScore
4.80
自引率
9.10%
发文量
1472
审稿时长
18.71 days
期刊介绍: Brain Sciences (ISSN 2076-3425) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications in the areas of cognitive neuroscience, developmental neuroscience, molecular and cellular neuroscience, neural engineering, neuroimaging, neurolinguistics, neuropathy, systems neuroscience, and theoretical and computational neuroscience. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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