Muhammad Attique Khan , Shrooq Alsenan , Shabbab Ali Algamdi , Haya Aldossary , K. Narasimha Raju , Jamel Baili , Muhammad Asim Saleem
{"title":"整合数据挖掘与经颅聚焦超声优化神经痛治疗策略。","authors":"Muhammad Attique Khan , Shrooq Alsenan , Shabbab Ali Algamdi , Haya Aldossary , K. Narasimha Raju , Jamel Baili , Muhammad Asim Saleem","doi":"10.1016/j.jneumeth.2025.110433","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Neuralgia and other neuropathic pain are difficult to treat owing to their complicated etiology and a wide variety of responses to treatment. The novel neuromodulation technology transcranial focused ultrasound (tFUS) has intriguing implications in targeted non-invasive brain stimulation. Patient-specific variables and neurological processes must be better understood to enhance tFUS for personalized therapy.</div></div><div><h3>Methods</h3><div>In this research, a Machine Learning based Transcranial Focused Ultrasound Personalized Model (ML-tFUSPM) has been proposed to treat neuralgia by combining tFUS with data mining for personalized therapy. Data mining algorithms can examine patient demographics, pain factors, imaging data, and therapy outcomes to uncover response patterns and treatment predictors. According to these results, tFUS may be tailored to each patient by targeting brain regions involved in pain perception and control.</div></div><div><h3>Results</h3><div>Initial studies show that data-driven models and tFUS enhance therapeutic efficacy, side effects, and accuracy. This collaborative endeavor uses data analytics and neuromodulation to customize neuralgia treatment. The new model's emphasis on targeted treatments and predictive analytics gives clinicians evidence-based tools to manage pain more effectively and personally, which might transform the industry.</div></div><div><h3>Comparative analysis</h3><div>The experimental results show that the proposed method has a high accuracy ratio of 97 % compared to other methods.</div></div><div><h3>Conclusion</h3><div>According to this study, computational principles and cutting-edge technology may lead to game-changing neurology and pain management advances.</div></div>","PeriodicalId":16415,"journal":{"name":"Journal of Neuroscience Methods","volume":"418 ","pages":"Article 110433"},"PeriodicalIF":2.7000,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Integrating data mining with transcranial focused ultrasound to refine neuralgia treatment strategies\",\"authors\":\"Muhammad Attique Khan , Shrooq Alsenan , Shabbab Ali Algamdi , Haya Aldossary , K. Narasimha Raju , Jamel Baili , Muhammad Asim Saleem\",\"doi\":\"10.1016/j.jneumeth.2025.110433\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Neuralgia and other neuropathic pain are difficult to treat owing to their complicated etiology and a wide variety of responses to treatment. The novel neuromodulation technology transcranial focused ultrasound (tFUS) has intriguing implications in targeted non-invasive brain stimulation. Patient-specific variables and neurological processes must be better understood to enhance tFUS for personalized therapy.</div></div><div><h3>Methods</h3><div>In this research, a Machine Learning based Transcranial Focused Ultrasound Personalized Model (ML-tFUSPM) has been proposed to treat neuralgia by combining tFUS with data mining for personalized therapy. Data mining algorithms can examine patient demographics, pain factors, imaging data, and therapy outcomes to uncover response patterns and treatment predictors. According to these results, tFUS may be tailored to each patient by targeting brain regions involved in pain perception and control.</div></div><div><h3>Results</h3><div>Initial studies show that data-driven models and tFUS enhance therapeutic efficacy, side effects, and accuracy. This collaborative endeavor uses data analytics and neuromodulation to customize neuralgia treatment. The new model's emphasis on targeted treatments and predictive analytics gives clinicians evidence-based tools to manage pain more effectively and personally, which might transform the industry.</div></div><div><h3>Comparative analysis</h3><div>The experimental results show that the proposed method has a high accuracy ratio of 97 % compared to other methods.</div></div><div><h3>Conclusion</h3><div>According to this study, computational principles and cutting-edge technology may lead to game-changing neurology and pain management advances.</div></div>\",\"PeriodicalId\":16415,\"journal\":{\"name\":\"Journal of Neuroscience Methods\",\"volume\":\"418 \",\"pages\":\"Article 110433\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-03-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Neuroscience Methods\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165027025000743\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neuroscience Methods","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165027025000743","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
Integrating data mining with transcranial focused ultrasound to refine neuralgia treatment strategies
Background
Neuralgia and other neuropathic pain are difficult to treat owing to their complicated etiology and a wide variety of responses to treatment. The novel neuromodulation technology transcranial focused ultrasound (tFUS) has intriguing implications in targeted non-invasive brain stimulation. Patient-specific variables and neurological processes must be better understood to enhance tFUS for personalized therapy.
Methods
In this research, a Machine Learning based Transcranial Focused Ultrasound Personalized Model (ML-tFUSPM) has been proposed to treat neuralgia by combining tFUS with data mining for personalized therapy. Data mining algorithms can examine patient demographics, pain factors, imaging data, and therapy outcomes to uncover response patterns and treatment predictors. According to these results, tFUS may be tailored to each patient by targeting brain regions involved in pain perception and control.
Results
Initial studies show that data-driven models and tFUS enhance therapeutic efficacy, side effects, and accuracy. This collaborative endeavor uses data analytics and neuromodulation to customize neuralgia treatment. The new model's emphasis on targeted treatments and predictive analytics gives clinicians evidence-based tools to manage pain more effectively and personally, which might transform the industry.
Comparative analysis
The experimental results show that the proposed method has a high accuracy ratio of 97 % compared to other methods.
Conclusion
According to this study, computational principles and cutting-edge technology may lead to game-changing neurology and pain management advances.
期刊介绍:
The Journal of Neuroscience Methods publishes papers that describe new methods that are specifically for neuroscience research conducted in invertebrates, vertebrates or in man. Major methodological improvements or important refinements of established neuroscience methods are also considered for publication. The Journal''s Scope includes all aspects of contemporary neuroscience research, including anatomical, behavioural, biochemical, cellular, computational, molecular, invasive and non-invasive imaging, optogenetic, and physiological research investigations.