人乳中胆固醇和极性脂质的全球水平和变化:系统回顾和荟萃分析

IF 6.2 1区 农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY
Xinggang Ni, Zhiyi Zhang, Ze-Yuan Deng, Sufang Duan, Ignatius Man-Yau Szeto, Jian He, Ting Li* and Jing Li*, 
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引用次数: 0

摘要

极性脂质和胆固醇是乳脂球膜的重要结构成分,在婴儿生长发育中起着至关重要的作用;然而,目前缺乏关于母乳中它们含量的系统的全球报告。本研究对中英文数据库进行了系统的文献检索,包括96项研究的69,392份人乳样本。基于全球数据的随机效应模型用于评估母乳中总脂、胆固醇、神经节苷和磷脂的含量及其随哺乳阶段、地理区域和样本年份的变化。总脂质、胆固醇和总磷脂的平均含量为2774.15 mg/100 g (95% CI:2614.88, 2933.42毫克/ 100克),21.15毫克/ 100克(18.35,23.95毫克/ 100克)和70.72毫克/ 100克(68.84,72.60毫克/ 100克),分别与神经节甘脂GM3和GD3 0.63毫克/ 100克(0.54,0.72毫克/ 100克)和0.34毫克/ 100克(0.32,0.36毫克/ 100克)。主要的磷脂SM, PC, PE、PS,和π平均为24.19毫克/ 100 g(23.17和25.21毫克/ 100克),21.27毫克/ 100克(19.92和22.62毫克/ 100克),18.28毫克/ 100克(17.46和19.10毫克/ 100克),2.86毫克/ 100克(2.32和3.40毫克/ 100克),和2.12 mg/100 g(1.75和2.49 mg/100 g)。随着泌乳的进展,总脂、神经节苷和大部分磷脂(SM、PC、PS、PI)升高,胆固醇和PE降低。多年来,总脂、神经节苷和PE呈上升趋势,而胆固醇和大多数磷脂呈下降趋势。与其他地区相比,欧洲母乳的总脂质和胆固醇水平较低。而总磷脂含量没有显著的区域差异(P >;0.05),观察磷脂组成的变化。这些发现强调了了解人乳脂质的时空变化对于制定个性化营养策略以支持最佳婴儿生长和发育的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Global Levels and Variations of Cholesterol and Polar Lipids of Human Milk: A Systematic Review and Meta-analysis

Global Levels and Variations of Cholesterol and Polar Lipids of Human Milk: A Systematic Review and Meta-analysis

Polar lipids and cholesterol are vital structural components of the milk fat globule membrane, playing a crucial role in infant growth and development; however, systematic global reports on their content in human milk are currently lacking. This study conducted a systematic literature search in Chinese and English databases, including 69,392 human milk samples from 96 studies. A random-effects model based on global data was used to assess the content of total lipids, cholesterol, gangliosides, and phospholipids in human milk and their variations with the lactation stage, geographical region, and sample year. The mean contents of total lipids, cholesterol, and total phospholipids were 2774.15 mg/100 g (95% CI: 2614.88, 2933.42 mg/100 g), 21.15 mg/100 g (18.35, 23.95 mg/100 g), and 70.72 mg/100 g (68.84, 72.60 mg/100 g), respectively, with gangliosides GM3 and GD3 at 0.63 mg/100 g (0.54, 0.72 mg/100 g) and 0.34 mg/100 g (0.32, 0.36 mg/100 g). The major phospholipids SM, PC, PE, PS, and PI averaged 24.19 mg/100 g (23.17 and 25.21 mg/100 g), 21.27 mg/100 g (19.92 and 22.62 mg/100 g), 18.28 mg/100 g (17.46 and 19.10 mg/100 g), 2.86 mg/100 g (2.32 and 3.40 mg/100 g), and 2.12 mg/100 g (1.75 and 2.49 mg/100 g). With the progression of lactation, total lipids, gangliosides, and most phospholipids (SM, PC, PS, PI) increased, while cholesterol and PE decreased. Over the years, total lipids, gangliosides, and PE showed an upward trend, whereas cholesterol and most phospholipids declined. Human milk from Europe had lower total lipid and cholesterol levels compared with other regions. While the total phospholipid content did not show significant regional differences (P > 0.05), variations in phospholipid composition were observed. These findings emphasize the importance of understanding spatiotemporal changes in human milk lipids to develop personalized nutrition strategies that support optimal infant growth and development.

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来源期刊
Journal of Agricultural and Food Chemistry
Journal of Agricultural and Food Chemistry 农林科学-农业综合
CiteScore
9.90
自引率
8.20%
发文量
1375
审稿时长
2.3 months
期刊介绍: The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.
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