{"title":"百里香、孜然和漆树提取物对肝癌细胞凋亡和旁凋亡的影响：协同作用、拮抗作用或添加剂性质","authors":"Yagmur Yasar Firat, Betul Cicek, Ayca Kara, Nurefsan Konyaligil Ozturk, Selen Ilgun","doi":"10.1002/fsn3.70106","DOIUrl":null,"url":null,"abstract":"<p>This study evaluated the effect of single, double, and triple combined doses of sumac, thyme, and cumin extracts on apoptosis and paraptosis in the HepG2 cell line. The effect of thyme and cumin extracts was higher in proteins (mTOR, caspase-8, caspase-9, Bax and bcl-2) other than caspase-3 protein. The expression of caspase-3 protein was higher in the sumac extract-treated groups. The expression levels of GRP78/Bip and DDIT3/Chop proteins, which are indicators of paraptosis, did not exert a significant difference between the extracts. Even though their protein expression is different, according to MTT results, sumac and thyme extracts showed an additive effect, thyme and cumin extracts showed an antagonistic effect, sumac and cumin extracts showed a synergistic effect, and sumac, thyme, and cumin extracts showed a synergistic effect. Sumac, thyme, and cumin extracts induced cell death by causing apoptosis in HepG2 cells, and they may have a supportive impact on the treatment of hepatocellular carcinoma.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70106","citationCount":"0","resultStr":"{\"title\":\"Effects of Thyme, Cumin, and Sumac Extracts on Apoptosis and Paraptosis in Hepatocellular Carcinoma: Synergistic, Antagonistic, or Additive Properties\",\"authors\":\"Yagmur Yasar Firat, Betul Cicek, Ayca Kara, Nurefsan Konyaligil Ozturk, Selen Ilgun\",\"doi\":\"10.1002/fsn3.70106\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>This study evaluated the effect of single, double, and triple combined doses of sumac, thyme, and cumin extracts on apoptosis and paraptosis in the HepG2 cell line. The effect of thyme and cumin extracts was higher in proteins (mTOR, caspase-8, caspase-9, Bax and bcl-2) other than caspase-3 protein. The expression of caspase-3 protein was higher in the sumac extract-treated groups. The expression levels of GRP78/Bip and DDIT3/Chop proteins, which are indicators of paraptosis, did not exert a significant difference between the extracts. Even though their protein expression is different, according to MTT results, sumac and thyme extracts showed an additive effect, thyme and cumin extracts showed an antagonistic effect, sumac and cumin extracts showed a synergistic effect, and sumac, thyme, and cumin extracts showed a synergistic effect. Sumac, thyme, and cumin extracts induced cell death by causing apoptosis in HepG2 cells, and they may have a supportive impact on the treatment of hepatocellular carcinoma.</p>\",\"PeriodicalId\":12418,\"journal\":{\"name\":\"Food Science & Nutrition\",\"volume\":\"13 4\",\"pages\":\"\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-03-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70106\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Science & Nutrition\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/fsn3.70106\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Science & Nutrition","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/fsn3.70106","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Effects of Thyme, Cumin, and Sumac Extracts on Apoptosis and Paraptosis in Hepatocellular Carcinoma: Synergistic, Antagonistic, or Additive Properties
This study evaluated the effect of single, double, and triple combined doses of sumac, thyme, and cumin extracts on apoptosis and paraptosis in the HepG2 cell line. The effect of thyme and cumin extracts was higher in proteins (mTOR, caspase-8, caspase-9, Bax and bcl-2) other than caspase-3 protein. The expression of caspase-3 protein was higher in the sumac extract-treated groups. The expression levels of GRP78/Bip and DDIT3/Chop proteins, which are indicators of paraptosis, did not exert a significant difference between the extracts. Even though their protein expression is different, according to MTT results, sumac and thyme extracts showed an additive effect, thyme and cumin extracts showed an antagonistic effect, sumac and cumin extracts showed a synergistic effect, and sumac, thyme, and cumin extracts showed a synergistic effect. Sumac, thyme, and cumin extracts induced cell death by causing apoptosis in HepG2 cells, and they may have a supportive impact on the treatment of hepatocellular carcinoma.
期刊介绍：
Food Science & Nutrition is the peer-reviewed journal for rapid dissemination of research in all areas of food science and nutrition. The Journal will consider submissions of quality papers describing the results of fundamental and applied research related to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.
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