Glutathione responsive curcumin delivery via amino acid covalently grafted cyclodextrin metal organic framework coated with soy hull polysaccharides

To enhance the selective release of curcumin (Cur), a novel metal organic framework (Cys-γ-CD-MOF) was designed to achieve glutathione (GSH)-triggered Cur release. Soy hull polysaccharide (SHP) was used as a coating on the surface of Cys-γ-CD-MOF, to reduce potential side effects and improve intestine bioavailability. Crystal structure analysis confirmed that the SHP coating did not disrupt the inherent crystallinity of Cys-γ-CD-MOF. Scanning electron microscope (SEM) revealed a regular cubic morphology for Cys-γ-CD-MOF. Cur was incorporated in an amorphous form in the carrier, achieving maximum loading and encapsulation efficiencies of 51.99 % at a 1:3 Cur-to-carrier ratio after soaking 24 h at 35 °C. Cys-γ-CD-MOF@SHP loaded with Cur exhibits selective release in GSH solution, with a cumulative release of 56.39 % after 24 h in a 10 mM GSH solution. These findings indicate that Cys-γ-CD-MOF@SHP can serve as a promising novel carrier for the delivery of Cur or other hydrophobic bioactive compounds.