Nicolas Pardey, Ricarda Schmidt, Jan Zeidler, Anja Hilbert
{"title":"德国对暴饮暴食症青少年认知行为疗法的健康经济评估。","authors":"Nicolas Pardey, Ricarda Schmidt, Jan Zeidler, Anja Hilbert","doi":"10.1002/eat.24413","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To determine the cost-effectiveness of cognitive-behavioral therapy (CBT) for adolescents with binge-eating disorder (BED), focusing on the costs per binge-free episode and per quality-adjusted life year (QALY) gained in comparison to a waitlist (WL) control group.</p><p><strong>Method: </strong>In the prospective, randomized superiority Binge-Eating Disorder in Adolescents (BEDA) trial, evaluating the efficacy of CBT with 20 individual sessions over 4 months versus WL, clinical and cost data were assessed at baseline and after 4 months. Missing values were imputed using multiple imputation techniques. The incremental cost-effectiveness ratio (ICER) was calculated. To reflect uncertainty, nonparametric bootstrapping was performed, and the results were presented in the form of cost-effectiveness acceptability curves (CEACs).</p><p><strong>Results: </strong>The study population consisted of 73 adolescents (82.2% female, mean age: 15.5 ± 2.6 years). Participants receiving CBT (n = 37) exhibited 4.7 more binge-free episodes (p = 0.0056) than the WL group (n = 36). The ICER was €46.70 for the gain of a binge-free episode and €128,861 for the gain of a QALY.</p><p><strong>Discussion: </strong>The probability of cost-effectiveness for achieving a binge-free episode is > 95% at a willingness-to-pay of €101. In terms of QALYs, CBT for BED may be a cost-effective intervention. A longer follow-up period may have yielded more favorable cost-effectiveness results.</p><p><strong>Trial registration: </strong>German Clinical Trials Register, https://www.drks.de, DRKS00000542.</p>","PeriodicalId":51067,"journal":{"name":"International Journal of Eating Disorders","volume":" ","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Health Economic Evaluation of Cognitive-Behavioral Therapy for Adolescents With Binge-Eating Disorder in Germany.\",\"authors\":\"Nicolas Pardey, Ricarda Schmidt, Jan Zeidler, Anja Hilbert\",\"doi\":\"10.1002/eat.24413\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To determine the cost-effectiveness of cognitive-behavioral therapy (CBT) for adolescents with binge-eating disorder (BED), focusing on the costs per binge-free episode and per quality-adjusted life year (QALY) gained in comparison to a waitlist (WL) control group.</p><p><strong>Method: </strong>In the prospective, randomized superiority Binge-Eating Disorder in Adolescents (BEDA) trial, evaluating the efficacy of CBT with 20 individual sessions over 4 months versus WL, clinical and cost data were assessed at baseline and after 4 months. Missing values were imputed using multiple imputation techniques. The incremental cost-effectiveness ratio (ICER) was calculated. To reflect uncertainty, nonparametric bootstrapping was performed, and the results were presented in the form of cost-effectiveness acceptability curves (CEACs).</p><p><strong>Results: </strong>The study population consisted of 73 adolescents (82.2% female, mean age: 15.5 ± 2.6 years). Participants receiving CBT (n = 37) exhibited 4.7 more binge-free episodes (p = 0.0056) than the WL group (n = 36). The ICER was €46.70 for the gain of a binge-free episode and €128,861 for the gain of a QALY.</p><p><strong>Discussion: </strong>The probability of cost-effectiveness for achieving a binge-free episode is > 95% at a willingness-to-pay of €101. In terms of QALYs, CBT for BED may be a cost-effective intervention. A longer follow-up period may have yielded more favorable cost-effectiveness results.</p><p><strong>Trial registration: </strong>German Clinical Trials Register, https://www.drks.de, DRKS00000542.</p>\",\"PeriodicalId\":51067,\"journal\":{\"name\":\"International Journal of Eating Disorders\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2025-03-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Eating Disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/eat.24413\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Eating Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/eat.24413","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Health Economic Evaluation of Cognitive-Behavioral Therapy for Adolescents With Binge-Eating Disorder in Germany.
Objective: To determine the cost-effectiveness of cognitive-behavioral therapy (CBT) for adolescents with binge-eating disorder (BED), focusing on the costs per binge-free episode and per quality-adjusted life year (QALY) gained in comparison to a waitlist (WL) control group.
Method: In the prospective, randomized superiority Binge-Eating Disorder in Adolescents (BEDA) trial, evaluating the efficacy of CBT with 20 individual sessions over 4 months versus WL, clinical and cost data were assessed at baseline and after 4 months. Missing values were imputed using multiple imputation techniques. The incremental cost-effectiveness ratio (ICER) was calculated. To reflect uncertainty, nonparametric bootstrapping was performed, and the results were presented in the form of cost-effectiveness acceptability curves (CEACs).
Results: The study population consisted of 73 adolescents (82.2% female, mean age: 15.5 ± 2.6 years). Participants receiving CBT (n = 37) exhibited 4.7 more binge-free episodes (p = 0.0056) than the WL group (n = 36). The ICER was €46.70 for the gain of a binge-free episode and €128,861 for the gain of a QALY.
Discussion: The probability of cost-effectiveness for achieving a binge-free episode is > 95% at a willingness-to-pay of €101. In terms of QALYs, CBT for BED may be a cost-effective intervention. A longer follow-up period may have yielded more favorable cost-effectiveness results.
Trial registration: German Clinical Trials Register, https://www.drks.de, DRKS00000542.
期刊介绍：
Articles featured in the journal describe state-of-the-art scientific research on theory, methodology, etiology, clinical practice, and policy related to eating disorders, as well as contributions that facilitate scholarly critique and discussion of science and practice in the field. Theoretical and empirical work on obesity or healthy eating falls within the journal’s scope inasmuch as it facilitates the advancement of efforts to describe and understand, prevent, or treat eating disorders. IJED welcomes submissions from all regions of the world and representing all levels of inquiry (including basic science, clinical trials, implementation research, and dissemination studies), and across a full range of scientific methods, disciplines, and approaches.
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