{"title":"韩国成年人饮食中omega-6与omega-3脂肪酸比例与年龄相关性黄斑变性之间的关系","authors":"Won Jang, Yuna Kim, Hyesook Kim","doi":"10.1186/s12937-025-01090-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Long-chain polyunsaturated fatty acids of the omega-6 and omega-3 families affect processes implicated in vascular and neural retinal disease pathogenesis. This study aimed to investigate the association between the dietary omega-6 to omega-3 fatty acid ratio and age-related macular degeneration (AMD).</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis using a nationwide representative sample of older adults (≥ 50 years), including 1,944 men and 2,592 women, from the Korea National Health and Nutrition Examination Survey (2017-2018). Omega-6 and omega-3 fatty acid intakes were collected through a 24-hour recall method and used to calculate the omega-6 to omega-3 fatty acid ratio. Associations between the ratio and AMD were determined using odds ratios (ORs) from multivariate logistic regressions.</p><p><strong>Results: </strong>The prevalence of AMD was 19.8% and 17.7% in Korean men and women, respectively. In women, the multivariable-adjusted OR for incurring AMD was significantly higher in the 2nd (OR = 1.36; 95% CI = 1.02-1.81) and 3rd (OR = 1.36; 95% CI = 1.02-1.83) tertiles of the dietary omega-6 to omega-3 fatty acid ratio than in the 1st tertile (OR = 1, the reference OR) (P = 0.036 for this trend). However, this association was not observed in men.</p><p><strong>Conclusions: </strong>These results suggest that high omega-6 to omega-3 fatty acid ratios may be associated with an increased prevalence of AMD among Korean women.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"29"},"PeriodicalIF":4.4000,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892259/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between the dietary omega-6 to omega-3 fatty acid ratio and age-related macular degeneration in Korean adults.\",\"authors\":\"Won Jang, Yuna Kim, Hyesook Kim\",\"doi\":\"10.1186/s12937-025-01090-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Long-chain polyunsaturated fatty acids of the omega-6 and omega-3 families affect processes implicated in vascular and neural retinal disease pathogenesis. This study aimed to investigate the association between the dietary omega-6 to omega-3 fatty acid ratio and age-related macular degeneration (AMD).</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis using a nationwide representative sample of older adults (≥ 50 years), including 1,944 men and 2,592 women, from the Korea National Health and Nutrition Examination Survey (2017-2018). Omega-6 and omega-3 fatty acid intakes were collected through a 24-hour recall method and used to calculate the omega-6 to omega-3 fatty acid ratio. Associations between the ratio and AMD were determined using odds ratios (ORs) from multivariate logistic regressions.</p><p><strong>Results: </strong>The prevalence of AMD was 19.8% and 17.7% in Korean men and women, respectively. In women, the multivariable-adjusted OR for incurring AMD was significantly higher in the 2nd (OR = 1.36; 95% CI = 1.02-1.81) and 3rd (OR = 1.36; 95% CI = 1.02-1.83) tertiles of the dietary omega-6 to omega-3 fatty acid ratio than in the 1st tertile (OR = 1, the reference OR) (P = 0.036 for this trend). However, this association was not observed in men.</p><p><strong>Conclusions: </strong>These results suggest that high omega-6 to omega-3 fatty acid ratios may be associated with an increased prevalence of AMD among Korean women.</p>\",\"PeriodicalId\":19203,\"journal\":{\"name\":\"Nutrition Journal\",\"volume\":\"24 1\",\"pages\":\"29\"},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2025-03-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892259/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12937-025-01090-z\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12937-025-01090-z","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
摘要
背景：omega-6和omega-3家族的长链多不饱和脂肪酸影响血管和神经视网膜疾病的发病过程。本研究旨在探讨饮食中omega-6与omega-3脂肪酸比例与年龄相关性黄斑变性（AMD）之间的关系。方法：我们使用来自韩国国家健康与营养检查调查（2017-2018）的全国老年人（≥50岁）代表性样本进行了横断面分析，其中包括1944名男性和2592名女性。通过24小时召回法收集Omega-6和omega-3脂肪酸的摄入量，并用于计算Omega-6与omega-3脂肪酸的比值。使用多变量logistic回归的比值比（ORs）确定该比率与AMD之间的关联。结果：韩国男性和女性AMD患病率分别为19.8%和17.7%。在女性中，发生AMD的多变量调整OR在第2期明显更高(OR = 1.36；95% CI = 1.02-1.81)和3 (OR = 1.36；95% CI = 1.02-1.83) 1个1分位数的膳食中omega-6与omega-3脂肪酸的比值高于1个1分位数（OR = 1，参考OR） （P = 0.036）。然而，在男性中没有观察到这种关联。结论：这些结果表明，高omega-6与omega-3脂肪酸比例可能与韩国女性AMD患病率增加有关。
Association between the dietary omega-6 to omega-3 fatty acid ratio and age-related macular degeneration in Korean adults.
Background: Long-chain polyunsaturated fatty acids of the omega-6 and omega-3 families affect processes implicated in vascular and neural retinal disease pathogenesis. This study aimed to investigate the association between the dietary omega-6 to omega-3 fatty acid ratio and age-related macular degeneration (AMD).
Methods: We conducted a cross-sectional analysis using a nationwide representative sample of older adults (≥ 50 years), including 1,944 men and 2,592 women, from the Korea National Health and Nutrition Examination Survey (2017-2018). Omega-6 and omega-3 fatty acid intakes were collected through a 24-hour recall method and used to calculate the omega-6 to omega-3 fatty acid ratio. Associations between the ratio and AMD were determined using odds ratios (ORs) from multivariate logistic regressions.
Results: The prevalence of AMD was 19.8% and 17.7% in Korean men and women, respectively. In women, the multivariable-adjusted OR for incurring AMD was significantly higher in the 2nd (OR = 1.36; 95% CI = 1.02-1.81) and 3rd (OR = 1.36; 95% CI = 1.02-1.83) tertiles of the dietary omega-6 to omega-3 fatty acid ratio than in the 1st tertile (OR = 1, the reference OR) (P = 0.036 for this trend). However, this association was not observed in men.
Conclusions: These results suggest that high omega-6 to omega-3 fatty acid ratios may be associated with an increased prevalence of AMD among Korean women.
期刊介绍：
Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered.
Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies.
In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
