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IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current pharmaceutical design Pub Date : 2025-03-05 DOI:10.2174/0113816128355783250212043621

Wafaa A Zaghary, Galal H Elgemeie, Rasha A Azzam, Safa A Aljuhr, Tamer M Sakr

引用次数: 0

摘要

苯并噻唑衍生物因其多用途的化学支架和显著的生物活性而备受关注。文章深入分析了 2020 年至 2024 年期间为提高这些化合物的抗癌潜力而采用的各种结构修饰和策略。文章讨论了结构-活性关系（SAR）和计算方法在优化苯并噻唑衍生物以选择性有效治疗癌症方面的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Recent Developments in the Synthesis of Benzothiazoles and their Anti-cancer Mechanistic Discoveries.

Benzothiazole derivatives have garnered considerable attention owing to their versatile chemical scaffold and remarkable biological activities. The article provides an in-depth analysis of the diverse structural modifications and strategies employed to enhance the anticancer potential of these compounds from the period of 2020 to 2024. It discusses the role of structure-activity relationships (SAR) and computational approaches in optimizing benzothiazole derivatives for selective and effective cancer treatment.

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来源期刊

Current pharmaceutical design 医学-药学

CiteScore

6.30

自引率

0.00%

发文量

302

审稿时长

2 months

期刊介绍： Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.