CD138：细胞神经骨化瘤的潜在新型诊断标记物

IF 1.6 4区医学 Q3 DERMATOLOGY

Journal of Cutaneous Pathology Pub Date : 2025-03-03 DOI:10.1111/cup.14790

Sarah Williamson, Arlene Rosenberg, Sarmad Jassim, Stephen Somach

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引用次数: 0

摘要

背景：我们偶然观察到CD138 （syndecan-1）在细胞性神经瘤（CNT）中的表达，并试图研究这在这些肿瘤中是否一致。方法：我们对20例被诊断为CNT的皮肤活检标本进行CD138免疫组化染色，与更传统的CNT免疫组化染色、NKI/C3和MITF进行比较。对照病例包括黄色肉芽肿（XG），真皮Spitz痣和上皮样纤维组织细胞瘤（EFH），基于相似的组织病理形态。结果：CD138在95%的碳纳米管病例中呈膜状和网状细胞外表达。NKI/C3在83%的CNT中表达，MITF在72%中表达。在对照病例中，10%的XG、10%的真皮Spitz痣和17%的EFH表达CD138。结论：我们的数据表明CD138可能是诊断CNT的有用辅助标记物，特别是当与其他已建立的标记物（如NKI/C3和MITF）联合使用时。

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CD138: A Potential Novel Diagnostic Marker for Cellular Neurothekeoma

Background

We incidentally observed CD138 (syndecan-1) expression in a cellular neurothekeoma (CNT) and sought to investigate whether this is a consistent finding in these tumors.

Methods

We evaluated a series of 20 skin biopsy specimens diagnosed as CNT for CD138 immunohistochemical staining in comparison to the more traditional CNT immunohistochemical stains, NKI/C3 and MITF. Control cases of xanthogranuloma (XG), dermal Spitz nevi, and epithelioid fibrous histiocytomas (EFH) were included based on similar histopathologic morphology.

Results

CD138 expression in a membranous and reticulated extracellular pattern was observed in 95% of CNT cases evaluated. NKI/C3 was expressed in 83% of CNT, and MITF in 72%. Of the control cases, 10% of XG, 10% of dermal Spitz nevi, and 17% of EFH expressed CD138.

Conclusions

Our data suggest that CD138 may be a useful adjunctive marker in the diagnosis of CNT, particularly when utilized in a panel with other established markers such as NKI/C3 and MITF.

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来源期刊

Journal of Cutaneous Pathology 医学-病理学

CiteScore

3.20

自引率

5.90%

发文量

174

审稿时长

3-8 weeks

期刊介绍： Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.