利用人工智能和天然化合物:肝细胞癌诊断和治疗的创新方法。

IF 2.6 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Mohd Suhail, Mohammad Tarique, Shams Tabrez, Darshan Badal
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引用次数: 0

摘要

肝癌,特别是肝细胞癌(HCC),由于其高发病率和作为癌症相关死亡的第四大原因,仍然是一个重大的全球健康挑战。HCC占所有肝癌病例的75-85%,是全球第六大常见癌症。一些因素,包括晚期诊断、有限的治疗效果、对常规疗法的耐药性和不良副作用,阻碍了对HCC患者提供延长生命的护理。目前的治疗方案,如化疗、免疫治疗和辅助治疗往往伴有严重的副作用。因此,迫切需要改进诊断方法和替代治疗方法,以延长预期寿命并降低hcc相关死亡率。人工智能(AI)是一项新兴技术,为HCC的早期检测提供了有希望的进展。在替代治疗方面,天然化合物因其多样的生物活性,如抗肿瘤、抗病毒、抗菌、抗氧化、抗炎、肝保护、抗诱变和心脏保护作用,以及相对较低的副作用而受到广泛关注。这些化合物通过调节参与肝细胞癌发生和进展的关键分子通路,表现出保护肝脏的特性。本文综述了肝癌病因学、HCC发病机制中的治疗靶点、人工智能在其检测中的作用以及天然产物特别是类黄酮作为HCC预防和治疗药物的潜力,并重点介绍了它们的潜在作用机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Leveraging AI and Natural Compounds: Innovative Approaches in the Diagnosis and Treatment of Hepatocellular Carcinoma.

Liver cancer, particularly Hepatocellular Carcinoma (HCC), remains a significant global health challenge owing to its high incidence and position as the fourth leading cause of cancer-related mortality. HCC represents 75-85% of all liver cancer cases and ranks as the sixth most prevalent cancer globally. Several factors, including late-stage diagnosis, limited treatment effectiveness, resistance to conventional therapies, and adverse side effects, hinder the delivery of life-prolonging care to patients with HCC. Current treatment options such as chemotherapy, immunotherapy, and adjuvant therapy are often associated with severe side effects. Consequently, there is an urgent need for improved diagnostic methods and alternative therapeutic approaches to extend life expectancy and reduce HCC-related mortalities. Artificial Intelligence (AI) is an emerging technology that offers promising advances for the early detection of HCC. In terms of alternative treatments, natural compounds have garnered significant attention because of their diverse biological activities, such as antitumor, antiviral, antimicrobial, antioxidant, anti-inflammatory, hepatoprotective, antimutagenic, and cardioprotective effects, and their relatively lower side effect profiles. These compounds exhibit hepatoprotective properties by modulating key molecular pathways involved in HCC development and progression. This article provides an overview of recent advances in the understanding of liver cancer etiology, therapeutic targets in HCC pathogenesis, the role of AI in its detection, and the potential of natural products, particularly flavonoids, as preventive and therapeutic agents against HCC, highlighting their underlying mechanisms of action.

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来源期刊
CiteScore
6.30
自引率
0.00%
发文量
302
审稿时长
2 months
期刊介绍: Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.
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