Yuliang Wu, Yalu Yan, Xia Xiong, Rui Li, Sufang Duan, Mengxuan Tang, Ignatius Man-Yau Szeto, Hongnan Liu, Suzanne M. Hodgkinson, Paul J. Moughan, Philip Wescombe, Jianwu Wang, Yulong Yin
{"title":"婴儿配方奶粉中α-乳清蛋白与β-酪蛋白不同比例对哺乳仔猪回肠真消化率和肠道形态的影响","authors":"Yuliang Wu, Yalu Yan, Xia Xiong, Rui Li, Sufang Duan, Mengxuan Tang, Ignatius Man-Yau Szeto, Hongnan Liu, Suzanne M. Hodgkinson, Paul J. Moughan, Philip Wescombe, Jianwu Wang, Yulong Yin","doi":"10.1021/acs.jafc.4c10520","DOIUrl":null,"url":null,"abstract":"Breast milk (BM) is the optimal nutrition source for infants, providing highly digestible proteins. In contrast, the digestibility of proteins in infant formula (IF) varies, influenced by differences in proteins such as α-lactalbumin (α-La) and β-casein (β-CN). This study aimed to evaluate the true ileal digestibility (TID) of amino acids (AAs) in BM and IF with varying α-La and β-CN contents using neonatal piglets. Twenty-four 11-day-old piglets (4 groups; 6 replicates/group) received either a nitrogen-free diet, IF (high infant formula (HIF) with 1.74 g/100 α-La and 2.3 g/100 β-CN; low infant formula (LIF) with 1.07 g/100 α-La and 1.85 g/100 β-CN), or BM (1.82 g/100 α-La and 3.05 g/100 β-CN) for 7 days after 3 prefeed days. IF had higher concentrations of nitrogen, serine, threonine, and proline than BM. Glutamic acid was the most abundant AA in IF and BM, while methionine in BM and LIF or tryptophan in HIF was the least. BM showed the highest TID of AAs, with the LIF had the lowest. The HIF group’s TID for AAs, especially tryptophan, was similar to BM and significantly better than LIF. These results suggest that adjusting the α-La and β-CN ratio in IF can improve AA digestibility, approaching BM levels.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"85 1","pages":""},"PeriodicalIF":6.2000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of Different Ratios of α-Lactalbumin to β-Casein in Infant Formula on True Ileal Digestibility and Intestinal Morphology of Suckling Piglets\",\"authors\":\"Yuliang Wu, Yalu Yan, Xia Xiong, Rui Li, Sufang Duan, Mengxuan Tang, Ignatius Man-Yau Szeto, Hongnan Liu, Suzanne M. Hodgkinson, Paul J. Moughan, Philip Wescombe, Jianwu Wang, Yulong Yin\",\"doi\":\"10.1021/acs.jafc.4c10520\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Breast milk (BM) is the optimal nutrition source for infants, providing highly digestible proteins. In contrast, the digestibility of proteins in infant formula (IF) varies, influenced by differences in proteins such as α-lactalbumin (α-La) and β-casein (β-CN). This study aimed to evaluate the true ileal digestibility (TID) of amino acids (AAs) in BM and IF with varying α-La and β-CN contents using neonatal piglets. Twenty-four 11-day-old piglets (4 groups; 6 replicates/group) received either a nitrogen-free diet, IF (high infant formula (HIF) with 1.74 g/100 α-La and 2.3 g/100 β-CN; low infant formula (LIF) with 1.07 g/100 α-La and 1.85 g/100 β-CN), or BM (1.82 g/100 α-La and 3.05 g/100 β-CN) for 7 days after 3 prefeed days. IF had higher concentrations of nitrogen, serine, threonine, and proline than BM. Glutamic acid was the most abundant AA in IF and BM, while methionine in BM and LIF or tryptophan in HIF was the least. BM showed the highest TID of AAs, with the LIF had the lowest. The HIF group’s TID for AAs, especially tryptophan, was similar to BM and significantly better than LIF. These results suggest that adjusting the α-La and β-CN ratio in IF can improve AA digestibility, approaching BM levels.\",\"PeriodicalId\":41,\"journal\":{\"name\":\"Journal of Agricultural and Food Chemistry\",\"volume\":\"85 1\",\"pages\":\"\"},\"PeriodicalIF\":6.2000,\"publicationDate\":\"2025-03-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Agricultural and Food Chemistry\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1021/acs.jafc.4c10520\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"AGRICULTURE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Agricultural and Food Chemistry","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1021/acs.jafc.4c10520","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURE, MULTIDISCIPLINARY","Score":null,"Total":0}
Effect of Different Ratios of α-Lactalbumin to β-Casein in Infant Formula on True Ileal Digestibility and Intestinal Morphology of Suckling Piglets
Breast milk (BM) is the optimal nutrition source for infants, providing highly digestible proteins. In contrast, the digestibility of proteins in infant formula (IF) varies, influenced by differences in proteins such as α-lactalbumin (α-La) and β-casein (β-CN). This study aimed to evaluate the true ileal digestibility (TID) of amino acids (AAs) in BM and IF with varying α-La and β-CN contents using neonatal piglets. Twenty-four 11-day-old piglets (4 groups; 6 replicates/group) received either a nitrogen-free diet, IF (high infant formula (HIF) with 1.74 g/100 α-La and 2.3 g/100 β-CN; low infant formula (LIF) with 1.07 g/100 α-La and 1.85 g/100 β-CN), or BM (1.82 g/100 α-La and 3.05 g/100 β-CN) for 7 days after 3 prefeed days. IF had higher concentrations of nitrogen, serine, threonine, and proline than BM. Glutamic acid was the most abundant AA in IF and BM, while methionine in BM and LIF or tryptophan in HIF was the least. BM showed the highest TID of AAs, with the LIF had the lowest. The HIF group’s TID for AAs, especially tryptophan, was similar to BM and significantly better than LIF. These results suggest that adjusting the α-La and β-CN ratio in IF can improve AA digestibility, approaching BM levels.
期刊介绍:
The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.