- Book学术

发布求助

文献互助智能选刊最新文献

IF 3.5 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2025-02-25 DOI:10.1016/j.brainresbull.2025.111278

Sama Rahnemayan , Arezoo Fathalizadeh , Mehdi Behroozi , Mahnaz Talebi , Amirreza Naseri , Elham Mehdizadehfar

{"title":"FMRI insights into the neural alterations and clinical correlates in multiple sclerosis: A comprehensive overview of systematic reviews and meta-analyses","authors":"Sama Rahnemayan , Arezoo Fathalizadeh , Mehdi Behroozi , Mahnaz Talebi , Amirreza Naseri , Elham Mehdizadehfar","doi":"10.1016/j.brainresbull.2025.111278","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammatory demyelination in the central nervous system. Functional Magnetic Resonance Imaging (fMRI) has emerged as an effective method for studying MS pathology. This review provides a comprehensive overview of fMRI applications, clarifying alterations in brain activity and identifying relevant biomarkers.</div></div><div><h3>Methods</h3><div>A systematic search of electronic databases and manual reference list checks at March 2024 yielded 470 articles. After duplicate removal, 456 articles underwent screening, 44 were assessed in full, and 12 systematic reviews and meta-analyses met inclusion criteria. Quality assessment was conducted.</div></div><div><h3>Results</h3><div>Included studies reported high methodological quality. fMRI revealed decreased functional connectivity within the default mode network, correlating with impaired information processing speed, and increased connectivity in compensatory networks during working memory tasks. Graph theory metrics identified disrupted global efficiency and clustering in functional networks, linked to gray matter atrophy. Neuroplasticity studies demonstrated cortical reorganization after cognitive rehabilitation, particularly in the prefrontal cortex. MS-related fatigue was associated with altered anterior cingulate cortex and thalamic activity, while depression correlated with reduced amygdala-prefrontal connectivity.</div></div><div><h3>Discussion</h3><div>fMRI has enhanced understanding of MS, revealing specific neural correlates of cognitive decline, neuroplasticity, fatigue, and depression. However, variability in MS subtypes and non-standardized protocols hinder consistency, while motion artifacts and cerebral blood flow changes complicate interpretation. Standardizing imaging protocols and integrating novel techniques could improve reliability and enable clinical applications to optimize patient monitoring and interventions.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"223 ","pages":"Article 111278"},"PeriodicalIF":3.5000,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Research Bulletin","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0361923025000905","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

导言：多发性硬化症（MS）是一种以中枢神经系统炎症性脱髓鞘为特征的慢性自身免疫性疾病。功能磁共振成像（fMRI）已成为研究多发性硬化病理的有效方法。本综述全面概述了 fMRI 的应用，阐明了大脑活动的改变并确定了相关的生物标记物：方法：截至 2024 年 3 月，通过对电子数据库进行系统检索和人工检查参考文献列表，共检索到 470 篇文章。去除重复文章后，456 篇文章接受了筛选，44 篇接受了全面评估，12 篇系统综述和荟萃分析符合纳入标准。进行了质量评估：fMRI显示默认模式网络的功能连通性降低，这与信息处理速度受损有关，而在工作记忆任务中，补偿网络的连通性增加。图论指标发现，功能网络的全局效率和聚类受到破坏，这与灰质萎缩有关。神经可塑性研究表明，认知康复后皮质重组，尤其是在前额叶皮质。与多发性硬化症相关的疲劳与前扣带回皮层和丘脑活动的改变有关，而抑郁则与杏仁核-前额叶连接的减少有关。讨论：fMRI增强了人们对多发性硬化症的了解，揭示了认知能力下降、神经可塑性、疲劳和抑郁的特定神经相关性。然而，多发性硬化症亚型的多变性和非标准化方案妨碍了一致性，而运动伪影和脑血流变化则使解释复杂化。标准化成像方案和整合新技术可以提高可靠性，并使临床应用能够优化患者监测和干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

FMRI insights into the neural alterations and clinical correlates in multiple sclerosis: A comprehensive overview of systematic reviews and meta-analyses

Introduction

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammatory demyelination in the central nervous system. Functional Magnetic Resonance Imaging (fMRI) has emerged as an effective method for studying MS pathology. This review provides a comprehensive overview of fMRI applications, clarifying alterations in brain activity and identifying relevant biomarkers.

Methods

A systematic search of electronic databases and manual reference list checks at March 2024 yielded 470 articles. After duplicate removal, 456 articles underwent screening, 44 were assessed in full, and 12 systematic reviews and meta-analyses met inclusion criteria. Quality assessment was conducted.

Results

Included studies reported high methodological quality. fMRI revealed decreased functional connectivity within the default mode network, correlating with impaired information processing speed, and increased connectivity in compensatory networks during working memory tasks. Graph theory metrics identified disrupted global efficiency and clustering in functional networks, linked to gray matter atrophy. Neuroplasticity studies demonstrated cortical reorganization after cognitive rehabilitation, particularly in the prefrontal cortex. MS-related fatigue was associated with altered anterior cingulate cortex and thalamic activity, while depression correlated with reduced amygdala-prefrontal connectivity.

Discussion

fMRI has enhanced understanding of MS, revealing specific neural correlates of cognitive decline, neuroplasticity, fatigue, and depression. However, variability in MS subtypes and non-standardized protocols hinder consistency, while motion artifacts and cerebral blood flow changes complicate interpretation. Standardizing imaging protocols and integrating novel techniques could improve reliability and enable clinical applications to optimize patient monitoring and interventions.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.