急性髓性白血病的补充治疗策略：中药信号通路和靶点

IF 2.1 4区医学 Q3 HEMATOLOGY

Leukemia research Pub Date : 2025-02-26 DOI:10.1016/j.leukres.2025.107672

Qiaoliang Wu , Lei Zhong , Guibing Zhang , Liying Han , Jing Xie , Yao Xu

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引用次数: 0

摘要

白血病是一种造血系统的异质性恶性肿瘤，其特点是骨髓和外周血中骨髓或淋巴祖细胞分化受阻，增殖失控。目前，强化化疗方案和造血干细胞移植（HSCT）是各种类型白血病最常用的治疗方法。然而，它们与严重的副作用和多药耐药性有关。因此，开发具有足够治疗效果的新治疗方法来选择性地消除白血病细胞和改善白血病预后是至关重要的。中药因其多成分、多靶点的特点，作为急性髓性白血病（AML）的替代治疗方法受到广泛关注。越来越多的证据表明，中药通过调节各种生物过程来阻止AML的进展。在此，我们回顾了中医治疗AML的作用及其潜在的机制和靶点。我们的研究结果将促进中医治疗急性髓性白血病的进一步研究和临床应用。

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Complementing therapeutic strategies for acute myeloid leukemia: Signaling pathways and targets of traditional Chinese medicine

Leukemia is a heterogeneous malignant tumor of the hematopoietic system and is characterized by the blockage of differentiation and uncontrolled proliferation of myeloid or lymphoid progenitor cells in the bone marrow and peripheral blood. Currently, intensified chemotherapy regimens and hematopoietic stem cell transplantation (HSCT) are the most common treatment methods for various types of leukemia. However, they are associated with severe side effects and multidrug resistance. Therefore, developing new treatment approaches with sufficient therapeutic effects to eliminate leukemia cells and improve leukemia outcomes selectively is essential. Traditional Chinese Medicine (TCM) has received widespread attention as an alternative treatment for acute myeloid leukemia (AML) because of its multi-component and multi-target characteristics. Increasing evidence suggests that TCM blocks AML progression by regulating various biological processes. Herein, we review the effects of TCM therapies for AML and its potential mechanisms and targets. Our findings will promote further research and improve the clinical application of TCM in treating AML.

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来源期刊

Leukemia research 医学-血液学

CiteScore

4.00

自引率

3.70%

发文量

259

审稿时长

1 months

期刊介绍： Leukemia Research an international journal which brings comprehensive and current information to all health care professionals involved in basic and applied clinical research in hematological malignancies. The editors encourage the submission of articles relevant to hematological malignancies. The Journal scope includes reporting studies of cellular and molecular biology, genetics, immunology, epidemiology, clinical evaluation, and therapy of these diseases.