不同花源蜂蜜中多酚和抗坏血酸对肝脏酒精代谢的影响

IF 4.2 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Molecular Nutrition & Food Research Pub Date : 2025-02-23 DOI:10.1002/mnfr.202400539

Zhiwei Sun, Lanhua Liu, Xingjiang Li, Jinjing Zhang, Hao Zhou, Dongdong Mu, Yousheng Wang, Xuefeng Wu

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引用次数: 0

摘要

众所周知，蜂蜜能有效促进酒精代谢。然而，其单个化学成分系统对酒精代谢的影响及其作用机制尚未完全阐明。本研究利用外源物质构建了6种不同花型蜂蜜的多酚和抗坏血酸系统（PAAS），探讨了它们对肝脏酒精代谢的影响。PAAS由22种多酚（包括熊果苷和咖啡酸）和抗坏血酸组成。结果表明，PAAS提高了乙醇脱氢酶（ADH）活性和adh1的表达，但对乙醛脱氢酶（ALDH）和adh2的表达无显著影响，导致血中乙醇浓度下降，但对乙醛浓度没有影响。相关分析表明，熊果苷和反式-4-羟基肉桂酸是促进酒精代谢的重要潜在物质。此外，PAAS还可以通过调节肝脏中不饱和脂肪酸的生物合成、嘌呤代谢等代谢途径来减轻酒精的有害作用。这些发现揭示了PAAS促进肝脏酒精代谢和保护肝脏的机制，为探索蜂蜜协同促进酒精代谢的机制提供了理论基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Effects of Polyphenols and Ascorbic Acid in Honey From Diverse Floral Origins on Liver Alcohol Metabolism

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Effects of Polyphenols and Ascorbic Acid in Honey From Diverse Floral Origins on Liver Alcohol Metabolism

Honey is known to promote alcohol metabolism effectively. However, the effects of its individual chemical components system on alcohol metabolism and their mechanisms of action have not yet been fully elucidated. We constructed polyphenols and ascorbic acid systems (PAAS) of six different floral kinds of honey by exogenous substances, to investigate their effects on alcohol metabolism in the liver. PAAS consists of 22 kinds of polyphenols (including arbutin and caffeic acid) and ascorbic acid. The results demonstrated that PAAS improved the activity of alcohol dehydrogenase (ADH) and the expression of adh1, but had no significant effect on acetaldehyde dehydrogenase (ALDH) and expression of adh2, which caused a decrease in blood ethanol concentration but no difference in acetaldehyde concentration. Correlation analysis illustrated that arbutin and trans-4-hydroxycinnamic acid in PAAS were important potential substances for promoting alcohol metabolism. In addition, PAAS could also reduce the deleterious effects of alcohol by modulating unsaturated fatty acid biosynthesis, purine metabolism, and other metabolic pathways in the liver. These findings revealed the mechanisms by which PAAS promoted hepatic alcohol metabolism as well as protected the liver and provided a theoretical basis for exploring the mechanisms in honey synergistically promote alcohol metabolism.

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来源期刊

Molecular Nutrition & Food Research 工程技术-食品科技

CiteScore

8.70

自引率

1.90%

发文量

250

审稿时长

1.7 months

期刊介绍： Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.