用于脊髓刺激的带颜色调节 PDMS 封装层的软神经接口。

IF 2.7 4区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Neuroscience Methods Pub Date : 2025-02-19 DOI:10.1016/j.jneumeth.2025.110402

Minjie Wang , Yuan Zhang , Aiping Wang , Zhongxue Gan , Lihua Zhang , Xiaoyang Kang

{"title":"用于脊髓刺激的带颜色调节 PDMS 封装层的软神经接口。","authors":"Minjie Wang , Yuan Zhang , Aiping Wang , Zhongxue Gan , Lihua Zhang , Xiaoyang Kang","doi":"10.1016/j.jneumeth.2025.110402","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Spinal cord stimulation (SCS) plays a crucial role in treating various neurological diseases. Utilizing soft spinal cord electrodes in SCS allows for a better fit with the physiological structure of the spinal cord and reduces tissue damage. Polydimethylsiloxane (PDMS) has emerged as an ideal material for soft bioelectronics. However, micromachining soft PDMS bioelectronics devices with low thermal effects and high uniformity remains challenging.</div></div><div><h3>New method</h3><div>Here, we demonstrated a fully laser-micromachined soft neural interface for SCS. The native and color adjusted PDMS with variable absorbance characteristics were investigated in laser processing. In addition, we systematically evaluated the impact of electrode sizes on the electrochemical performance of neural interface. By fitting the equivalent circuit model, the electrochemical process of neural interface was revealed and the performance of the electrode was evaluated. The biocompatibility of color adjusted PDMS was confirmed by cytotoxicity assays. Finally, we validated the neural interface in mice.</div></div><div><h3>Results</h3><div>Color adjusted PDMS has good biocompatibility and can significantly reduce the damage caused by thermal effects, enhancing the electrochemical performance of bioelectronic devices. The soft neural interface with color adjusted PDMS encapsulation layer can activate the motor function safely.</div></div><div><h3>Comparison with existing methods</h3><div>The fully laser-micromachined soft neural interface was proposed for the first time. Compared with existing methods, this method showed low thermal effects, high uniformity, and could be easily scaled up.</div></div><div><h3>Conclusions</h3><div>The fully laser-micromachined soft neural interface device with color adjusted PDMS encapsulation layer shows great promise for applications in SCS.</div></div>","PeriodicalId":16415,"journal":{"name":"Journal of Neuroscience Methods","volume":"417 ","pages":"Article 110402"},"PeriodicalIF":2.7000,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Soft neural interface with color adjusted PDMS encapsulation layer for spinal cord stimulation\",\"authors\":\"Minjie Wang , Yuan Zhang , Aiping Wang , Zhongxue Gan , Lihua Zhang , Xiaoyang Kang\",\"doi\":\"10.1016/j.jneumeth.2025.110402\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Spinal cord stimulation (SCS) plays a crucial role in treating various neurological diseases. Utilizing soft spinal cord electrodes in SCS allows for a better fit with the physiological structure of the spinal cord and reduces tissue damage. Polydimethylsiloxane (PDMS) has emerged as an ideal material for soft bioelectronics. However, micromachining soft PDMS bioelectronics devices with low thermal effects and high uniformity remains challenging.</div></div><div><h3>New method</h3><div>Here, we demonstrated a fully laser-micromachined soft neural interface for SCS. The native and color adjusted PDMS with variable absorbance characteristics were investigated in laser processing. In addition, we systematically evaluated the impact of electrode sizes on the electrochemical performance of neural interface. By fitting the equivalent circuit model, the electrochemical process of neural interface was revealed and the performance of the electrode was evaluated. The biocompatibility of color adjusted PDMS was confirmed by cytotoxicity assays. Finally, we validated the neural interface in mice.</div></div><div><h3>Results</h3><div>Color adjusted PDMS has good biocompatibility and can significantly reduce the damage caused by thermal effects, enhancing the electrochemical performance of bioelectronic devices. The soft neural interface with color adjusted PDMS encapsulation layer can activate the motor function safely.</div></div><div><h3>Comparison with existing methods</h3><div>The fully laser-micromachined soft neural interface was proposed for the first time. Compared with existing methods, this method showed low thermal effects, high uniformity, and could be easily scaled up.</div></div><div><h3>Conclusions</h3><div>The fully laser-micromachined soft neural interface device with color adjusted PDMS encapsulation layer shows great promise for applications in SCS.</div></div>\",\"PeriodicalId\":16415,\"journal\":{\"name\":\"Journal of Neuroscience Methods\",\"volume\":\"417 \",\"pages\":\"Article 110402\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-02-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Neuroscience Methods\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165027025000433\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neuroscience Methods","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165027025000433","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}

引用次数: 0

摘要

背景：脊髓刺激（SCS）在治疗多种神经系统疾病中起着至关重要的作用。在SCS中使用脊髓软电极可以更好地适应脊髓的生理结构，减少组织损伤。聚二甲基硅氧烷（PDMS）已成为一种理想的软生物电子学材料。然而，具有低热效应和高均匀性的软PDMS生物电子器件的微加工仍然具有挑战性。新方法：在这里，我们展示了一个完全激光微加工的神经软接口。研究了具有变吸光度特性的天然PDMS和调色PDMS在激光加工中的应用。此外，我们系统地评估了电极尺寸对神经界面电化学性能的影响。通过拟合等效电路模型，揭示了神经界面的电化学过程，评价了电极的性能。通过细胞毒性实验证实了调色PDMS的生物相容性。最后，我们在小鼠身上验证了神经接口。结果：调色PDMS具有良好的生物相容性，可显著降低热效应造成的损伤，提高生物电子器件的电化学性能。柔软的神经接口，颜色可调的PDMS包封层，可以安全地激活运动功能。与现有方法的比较：首次提出了全激光微加工软神经接口。与现有方法相比，该方法具有热效应小、均匀性高、易于规模化等优点。结论：具有颜色可调PDMS包封层的全激光微加工软神经接口装置在SCS中具有广阔的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Soft neural interface with color adjusted PDMS encapsulation layer for spinal cord stimulation

Background

Spinal cord stimulation (SCS) plays a crucial role in treating various neurological diseases. Utilizing soft spinal cord electrodes in SCS allows for a better fit with the physiological structure of the spinal cord and reduces tissue damage. Polydimethylsiloxane (PDMS) has emerged as an ideal material for soft bioelectronics. However, micromachining soft PDMS bioelectronics devices with low thermal effects and high uniformity remains challenging.

New method

Here, we demonstrated a fully laser-micromachined soft neural interface for SCS. The native and color adjusted PDMS with variable absorbance characteristics were investigated in laser processing. In addition, we systematically evaluated the impact of electrode sizes on the electrochemical performance of neural interface. By fitting the equivalent circuit model, the electrochemical process of neural interface was revealed and the performance of the electrode was evaluated. The biocompatibility of color adjusted PDMS was confirmed by cytotoxicity assays. Finally, we validated the neural interface in mice.

Results

Color adjusted PDMS has good biocompatibility and can significantly reduce the damage caused by thermal effects, enhancing the electrochemical performance of bioelectronic devices. The soft neural interface with color adjusted PDMS encapsulation layer can activate the motor function safely.

Comparison with existing methods

The fully laser-micromachined soft neural interface was proposed for the first time. Compared with existing methods, this method showed low thermal effects, high uniformity, and could be easily scaled up.

Conclusions

The fully laser-micromachined soft neural interface device with color adjusted PDMS encapsulation layer shows great promise for applications in SCS.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Neuroscience Methods 医学-神经科学

CiteScore

7.10

自引率

3.30%

发文量

226

审稿时长

52 days

期刊介绍： The Journal of Neuroscience Methods publishes papers that describe new methods that are specifically for neuroscience research conducted in invertebrates, vertebrates or in man. Major methodological improvements or important refinements of established neuroscience methods are also considered for publication. The Journal''s Scope includes all aspects of contemporary neuroscience research, including anatomical, behavioural, biochemical, cellular, computational, molecular, invasive and non-invasive imaging, optogenetic, and physiological research investigations.