基于fmri的数据驱动脑分割,使用独立分量分析

IF 2.7 4区 医学 Q2 BIOCHEMICAL RESEARCH METHODS
William D. Reeves , Ishfaque Ahmed , Brooke S. Jackson , Wenwu Sun , Celestine F. Williams , Catherine L. Davis , Jennifer E. McDowell , Nathan E. Yanasak , Shaoyong Su , Qun Zhao
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引用次数: 0

摘要

使用功能磁共振成像(fMRI)进行的研究广泛需要一种将大脑分割成感兴趣区域(roi)的方法。包裹可以基于标准化的大脑解剖结构,如蒙特利尔神经学研究所(MNI)的152图谱,或个人的功能活动模式,如Personode软件。这项工作概述并测试了应用于高血压研究(n = 48)的基于独立成分分析(ICA)的分割算法(IPA),该算法使用独立成分分析(gICA)组的独立成分(ic)输出来构建理想的空间一致和功能均匀的roi。在对所有受试者的ic进行回归后,IPA构建个性化的分组,同时获得ica衍生的分组。结果由骰子相似系数(dsc)量化的roi空间一致性显示个性化的分割,平均dsc为0.69 ± 0.14。功能同质性,计算为构成ROI的所有体素的平均Pearson相关值,显示个性化包块的平均值为0.30 ± 0.14,而gica衍生包块的平均值为0.38 ± 0.15。与现有方法相比,个性化Personode分组显示平均dsc降低(0.43 ± 0.11),个性化分组、gica衍生分组和MNI图谱的均匀性值分别降低0.28 ± 0.14、0.31 ± 0.15和0.20 ± 0.11。结论IPA可以更可靠地定义ROI,并且具有更高的功能同质性。鉴于这些发现,IPA显示出作为一种新的包装技术,可以帮助分析功能磁共振成像数据的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
fMRI-based data-driven brain parcellation using independent component analysis

Background

Studies using functional magnetic resonance imaging (fMRI) broadly require a method of parcellating the brain into regions of interest (ROIs). Parcellations can be based on standardized brain anatomy, such as the Montreal Neurological Institute’s (MNI) 152 atlas, or an individual’s functional activity patterns, such as the Personode software.

New method

This work outlines and tests the independent component analysis (ICA)-based parcellation algorithm (IPA) when applied to a hypertension study (n = 48) that uses the independent components (ICs) output from group ICA (gICA) to build ROIs which are ideally spatially consistent and functionally homogeneous. After regression of ICs to all subjects, the IPA builds individualized parcellations while simultaneously obtaining a gICA-derived parcellation.

Results

ROI spatial consistency quantified by dice similarity coefficients (DSCs) show individualized parcellations exhibit mean DSCs of 0.69 ± 0.14. Functional homogeneity, calculated as mean Pearson correlation value of all voxels comprising a ROI, shows individualized parcellations with a mean of 0.30 ± 0.14 and gICA-derived parcellations’ mean of 0.38 ± 0.15.

Comparison with existing method(s)

Individualized Personode parcellations show decreased mean DSCs (0.43 ± 0.11) with the individualized parcellations, gICA-derived parcellations, and the MNI atlas having decreased homogeneity values of 0.28 ± 0.14, 0.31 ± 0.15, and 0.20 ± 0.11 respectively.

Conclusions

Results show that the IPA can more reliably define a ROI and does so with higher functional homogeneity. Given these findings, the IPA shows promise as a novel parcellation technique that could aid the analysis of fMRI data.
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来源期刊
Journal of Neuroscience Methods
Journal of Neuroscience Methods 医学-神经科学
CiteScore
7.10
自引率
3.30%
发文量
226
审稿时长
52 days
期刊介绍: The Journal of Neuroscience Methods publishes papers that describe new methods that are specifically for neuroscience research conducted in invertebrates, vertebrates or in man. Major methodological improvements or important refinements of established neuroscience methods are also considered for publication. The Journal''s Scope includes all aspects of contemporary neuroscience research, including anatomical, behavioural, biochemical, cellular, computational, molecular, invasive and non-invasive imaging, optogenetic, and physiological research investigations.
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