抗菌药物管理计划对法国大学医院适当使用碳青霉烯类药物的影响（CARBACAI研究）。

IF 2.2 4区医学 Q2 INFECTIOUS DISEASES

Infectious diseases now Pub Date : 2025-02-13 DOI:10.1016/j.idnow.2025.105039

Julia Santucci , Guillaume Saint-Lorant , Aurélie Baldolli , Christophe Isnard , Pascal Thibon , Arnaud de La Blanchardiere

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引用次数: 0

摘要

目的：研究碳青霉烯（CP）国家使用指南的符合性。患者和方法：我们在法国一家大学医院进行了一项为期两年的前瞻性单中心和介入性研究。该研究分为三个阶段（观察（P1）、干预（P2）和干预后（P3）），并在干预后10 个月结束。CP处方的依从性是基于预先确定的标准。结果：在评估的330张处方中，第3天的治疗充分性从P1阶段的32.3 % （n = 42/130）增加到P3阶段的72.2 % (n = 70/97)（p ）。结论：实施教育抗菌药物管理计划对医院抗菌药物的正确使用有积极影响。教育提醒对于支持这些改进是必不可少的。

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Impact of an antimicrobial stewardship program on the appropriate use of carbapenems in a French university hospital (CARBACAI study)

Objectives

To study compliance with national guidelines for carbapenem (CP) use.

Patients and methods

We performed a two-year prospective monocentric and interventional study in a French university hospital. The study was based on three phases (observation (P1), intervention (P2), and post-intervention (P3)) and ended 10 months after intervention. Compliance of CP prescriptions was based on predetermined criteria.

Results

Among the 330 prescriptions assessed, treatment adequacy on Day 3 increased from 32.3 % (n = 42/130) during phase P1 to 72.2 % (n = 70/97) during phase P3 (p < 0.01), with a significant impact on indications, dosage, and duration of treatment but not on CP choice. There were no significant changes in overall CP consumption.

Conclusions

Implementing an educational antimicrobial stewardship program for hospital CP proper use had a positive impact. Educational reminders are essential to support these improvements.

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