羊膜动物苍白膜感觉回路的进化趋同

IF 45.8 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-02-14

Eneritz Rueda-Alaña, Rodrigo Senovilla-Ganzo, Marco Grillo, Enrique Vázquez, Sergio Marco-Salas, Tatiana Gallego-Flores, Aitor Ordeñana-Manso, Artemis Ftara, Laura Escobar, Alberto Benguría, Ana Quintas, Ana Dopazo, Miriam Rábano, María dM Vivanco, Ana María Aransay, Daniel Garrigos, Ángel Toval, José Luis Ferrán, Mats Nilsson, Juan Manuel Encinas-Pérez, Maurizio De Pittà, Fernando García-Moreno

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引用次数: 0

摘要

白膜羊膜包含结构和功能相同的感觉回路，但它们的进化关系仍未解决。我们使用了出生年代分析、单细胞RNA和空间转录组学以及数学模型来比较鸟类（小鸡）、蜥蜴（壁虎）和哺乳动物（老鼠）中已知的苍白质回路的发育和进化。我们发现，这些回路中的神经元在不同物种的不同发育时间和大脑区域产生，并发现谷氨酸能神经元的转录组学进展存在早期发育差异。我们的研究强调了鸟类和哺乳动物之间感觉回路的发育差异和功能相似性，表明在羊膜动物谱系中，高阶感觉处理是趋同的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Evolutionary convergence of sensory circuits in the pallium of amniotes

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Evolutionary convergence of sensory circuits in the pallium of amniotes

The amniote pallium contains sensory circuits that are structurally and functionally equivalent, yet their evolutionary relationship remains unresolved. We used birthdating analysis, single-cell RNA and spatial transcriptomics, and mathematical modeling to compare the development and evolution of known pallial circuits across birds (chick), lizards (gecko), and mammals (mouse). We reveal that neurons within these circuits’ stations are generated at varying developmental times and brain regions across species and found an early developmental divergence in the transcriptomic progression of glutamatergic neurons. Our research highlights developmental distinctions and functional similarities in the sensory circuit between birds and mammals, suggesting the convergence of high-order sensory processing across amniote lineages.

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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