萝卜硫素对自闭症谱系障碍患者ABC和SRS量表的影响：荟萃分析

IF 1.4 4区医学 Q4 CLINICAL NEUROLOGY

Brain & Development Pub Date : 2025-02-14 DOI:10.1016/j.braindev.2025.104321

Jialing Guo , Yichao Wang , Weijun He , Mingxing Lou , Ying Peng , Hui Shi , Aojie Lian

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引用次数: 0

摘要

自闭症谱系障碍（ASD）已成为一个日益突出的全球性健康问题。萝卜硫素是一种具有多种功能的植物化学物质，针对与ASD相关的许多相同的生化和分子途径（生物标志物）。本研究旨在对萝卜硫素对ASD患者异常行为量表（ABC）和社会反应量表（SRS）的影响进行meta分析。我们对PubMed、Medline、Cochrane、EMBASE和Web of Science数据库进行了全面的检索。采用改进的Cochrane偏倚风险工具检查纳入研究的偏倚风险。采用Review Manager 5.3软件进行meta分析。本荟萃分析结果显示，萝卜硫素显著改善易怒和多动症状，提示萝卜硫素具有联合治疗自闭症的潜力。需要进一步的研究来证实和探索萝卜硫素的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Effects of sulforaphane on ABC and SRS scales in patients with autism spectrum disorder: a meta-analysis

Autism spectrum disorder (ASD) has become an increasingly prominent global health issue. Sulforaphane is a phytochemical with multiple functions that target many of the same biochemical and molecular pathways (biomarkers) associated with ASD. This study aimed to conduct a meta-analysis based on sulforaphane's effect on Aberrant Behavior Checklist (ABC) and Social Responsiveness Scale (SRS) in patients with ASD. We conducted comprehensive searches in the PubMed, Medline, Cochrane, EMBASE, and Web of Science databases from their inception. The modified Cochrane risk of bias tool was used to check the risk of bias of the included studies. Review Manager 5.3 software was used to conduct this meta-analysis. The results of this meta-analysis showed that sulforaphane significantly improved irritability and hyperactivity symptoms, suggesting that sulforaphane has the potential for the combined treatment of autism. Additional studies are needed to confirm and explore the effect of sulforaphane.

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来源期刊

Brain & Development 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

153

审稿时长

50 days

期刊介绍： Brain and Development (ISSN 0387-7604) is the Official Journal of the Japanese Society of Child Neurology, and is aimed to promote clinical child neurology and developmental neuroscience. The journal is devoted to publishing Review Articles, Full Length Original Papers, Case Reports and Letters to the Editor in the field of Child Neurology and related sciences. Proceedings of meetings, and professional announcements will be published at the Editor''s discretion. Letters concerning articles published in Brain and Development and other relevant issues are also welcome.