大豆来源的ace2激活肽IVPQ和IAVPT在ace2介导的内皮保护中的差异机制

IF 6.2 1区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of Agricultural and Food Chemistry Pub Date : 2025-02-07 DOI:10.1021/acs.jafc.4c08947

Minzhi Zhou, Tianyuan Song, Mingtao Huang, Lin Zheng, Mouming Zhao

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引用次数: 0

摘要

本研究旨在探讨大豆衍生肽IVPQ和IAVPT对angii诱导的人脐静脉内皮细胞（HUVECs）内皮功能障碍的调节作用及其通过ACE2激活的潜在机制。IVPQ和IAVPT通过激活ACE2/Ang-(1-7)/MasR轴，改善Ang II诱导的HUVECs恶性迁移和NO减少，导致Ang II降解和Ang II信号减少。这些保护作用被不同程度地削弱，这可能是由于激活ACE2的机制不同，其中IAVPT在浓度为1.0 × 10-4 M时直接激活ACE2，而IVPQ可能通过影响ACE2 mRNA的稳定性来上调ACE2。这些结果有助于我们理解ace2激活肽调节内皮功能的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Differential Mechanisms of Soybean-Derived ACE2-Activating Peptides IVPQ and IAVPT in ACE2-Mediated Endothelial Protection

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Differential Mechanisms of Soybean-Derived ACE2-Activating Peptides IVPQ and IAVPT in ACE2-Mediated Endothelial Protection

This study aimed to investigate the modulatory effects of soybean-derived peptides IVPQ and IAVPT, which were initially identified as potent ACE2-activating peptides, on Ang II-induced endothelial dysfunction in human umbilical vein endothelial cells (HUVECs) and the underlying mechanisms via ACE2 activation. IVPQ and IAVPT ameliorated Ang II-induced malignant migration and NO reduction in HUVECs via the activation of the ACE2/Ang-(1–7)/MasR axis, resulting in Ang II degradation and decreased Ang II signaling. These protective effects were attenuated by ACE2 knockdown to different degrees, which was possibly due to different mechanisms of activating ACE2, where IAVPT directly activated ACE2 at a concentration of 1.0 × 10^–4 M and IVPQ upregulated ACE2 likely through effects on ACE2 mRNA stability. These results contributed to our understanding of the mechanism of ACE2-activating peptides regulating endothelial function.

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来源期刊

Journal of Agricultural and Food Chemistry 农林科学-农业综合

CiteScore

9.90

自引率

8.20%

发文量

1375

审稿时长

2.3 months

期刊介绍： The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.